NFAT INHIBITOR
| 中文名称 | NFAT INHIBITOR |
|---|---|
| 中文同义词 | 11R-VIVIT游离态;L-蛋氨酰-L-丙氨酰甘氨酰-L-脯氨酰-L-组氨酰-L-脯氨酰-L-缬氨酰-L-异亮氨酰-L-缬氨酰-L-异亮氨酰-L-苏氨酰甘氨酰-L-脯氨酰-L-组氨酰-L-ALPHA-谷氨酰-L-谷氨酸;细胞渗透性肽抑制剂多肽H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH;化合物AGI-5198;NFAT INHIBITOR-1 |
| 英文名称 | H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH |
| 英文同义词 | MAGPHPVIVITGPHEE;MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU;H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH;NFAT INHIBITOR;VIVIT;NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%;NFAT INHIBITOR?, >98%;NFAT Inhibitor (VIVIT peptide) |
| CAS号 | 249537-73-3 |
| 分子式 | C75H118N20O22S |
| 分子量 | 1683.93 |
| EINECS号 | |
| 相关类别 | 多肽;目录多肽;Gene Regulation;Cell Signaling and Neuroscience;Gene Regulation and Expression |
| Mol文件 | 249537-73-3.mol |
| 结构式 |  |
NFAT INHIBITOR 性质
| 沸点 | 1982.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.334±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO：15 mg/ml；水：10 mg/ml |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.12±0.10(Predicted) |
| 水溶解性 | Soluble to 2 mg/ml in water |
| 序列 | H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH |
NFAT Inhibitor (VIVIT peptide) 是一种 NFAT 的细胞渗透性肽抑制剂，可选择性抑制钙调磷酸酶介导的 NFAT 脱磷酸作用。
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
Nuclear factor of activated Tcells (NFAT)
NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
Western Blot Analysis
| Cell Line: | Human peripheral blood CD14 + monocytes |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours or 21 days |
| Result: | Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9. |
参考质量标准
外观:白色粉末纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 海关编码 | 2933299090 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 1mg | 700元 |
| 2024/01/25 | HY-P1026 | NFAT INHIBITOR NFAT Inhibitor | 249537-73-3 | 5mg | 2800元 |