伊罗替罗
| 中文名称 | 伊罗替罗 |
|---|---|
| 中文同义词 | N-[3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基]丙酰胺酸;伊罗替罗;3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧丙酸;3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧代丙酸 |
| 英文名称 | Eprotirome |
| 英文同义词 | eprotirome;N-[3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid;3-((3,5-Dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid;Kb-2115;Unii-958aq7B6R1;Propanoic acid,3-[[3,5-dibroMo-4-[4-hydroxy-3-(1-Methylethyl)phenoxy]phenyl]aMino]-3-oxo-;3-((3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-3-oxopropanoic acid;KB2115 Exclusive |
| CAS号 | 355129-15-6 |
| 分子式 | C18H17Br2NO5 |
| 分子量 | 487.14 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 355129-15-6.mol |
| 结构式 |  |
伊罗替罗 性质
| 沸点 | 596.3±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.708 |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO:84.0(最大浓度 mg/mL);172.43(最大浓度 mM) DMF:30.0(最大浓度 mg/mL);61.58(最大浓度 mM) 乙醇:63.5(最大浓度 mg/mL);130.35(最大浓度 mM) 乙醇:PBS (pH 7.2) (1:1):0.5(最大浓度 mg/mL);1.03(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 3.16±0.32(Predicted) |
Eprotirome (KB2115) 是肝脏选择性甲状腺激素受体 (thyroid hormone receptor, TR) 激动剂。KB2115 对 TRβ 的亲和力略高于 TRα。Eprotirome 降低了低密度脂蛋白 (LDL) 胆固醇的浓度，可用于血脂异常和肥胖症的研究。
Thyroid hormone receptor
Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.