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| | (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER Basic information |
| Product Name: | (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER | | Synonyms: | CGP 39551;(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER;(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYLESTHER;2-Amino-4-methyl-5-phosphono-3 pentenoic acid carboxyethyl ester;3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, 1-ethyl ester, (3E)-;3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, 1-ethyl ester, (E)-(+-)-;(E)-(4-Amino-5-ethoxy-2-methyl-5-oxopent-2-en-1-yl)phosphonic acid;CGP 39551, competitive NMDA antagonist | | CAS: | 127910-32-1 | | MF: | C8H16NO5P | | MW: | 237.19 | | EINECS: | | | Product Categories: | Glutamate receptor;Glutamate | | Mol File: | 127910-32-1.mol |  |
| | (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER Chemical Properties |
| Boiling point | 434.1±55.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | H2O: soluble15mg/mL, clear | | form | powder | | pka | 2.30±0.10(Predicted) | | color | white to beige | | Water Solubility | Soluble to 100 mM in water |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER Usage And Synthesis |
| Uses | CGP 39551 is a potent, selective and competitive NMDA antagonist. | | Biological Activity | Potent, selective and competitive NMDA antagonist (K i = 310 nM for inhibition of [ 3 H]-CPP binding in rat brain). Centrally active upon oral administration in vivo . | | in vivo | CGP 39551 exhibits maximal electroshock-induced seizures in mice with the ED50 of 4 mg/kg (p.o.)[2].
Following chronic neonatal treatment with CGP 39551, adult rats show increased behavioral responses to the D2 dopamine receptor stimulation[3]. | | storage | Desiccate at +4°C |
| | (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER Preparation Products And Raw materials |
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