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| | 4-Bromo-5-fluoro-2-nitroaniline Basic information |
| Product Name: | 4-Bromo-5-fluoro-2-nitroaniline | | Synonyms: | Benzenamine,4-bromo-5-fluoro-2-nitro-;4-Bromo-5-fluoro-2-nitroaniline97%;4-Bromo-5-fluoro-2-nitroaniline;4-Bromo-5-fluoro-2-nitroaniline 97%;2-Amino-5-bromo-4-fluoronitrobenzene;4-Bromo-5-fluoro-2-nitrobenzenamine | | CAS: | 153505-36-3 | | MF: | C6H4BrFN2O2 | | MW: | 235.01 | | EINECS: | | | Product Categories: | | | Mol File: | 153505-36-3.mol |  |
| | 4-Bromo-5-fluoro-2-nitroaniline Chemical Properties |
| Boiling point | 313.9±37.0 °C(Predicted) | | density | 1.896±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -2.19±0.25(Predicted) | | Appearance | Light yellow to yellow Solid |
| Hazard Codes | T | | HS Code | 2921420090 |
| | 4-Bromo-5-fluoro-2-nitroaniline Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 4-bromo-5-fluoro-2-nitroaniline, using the compound (CAS: 929279-27-6) as starting material, was as follows:Preparation of Intermediate 11B: To (4-bromo-5-fluoro-2-nitrophenyl)-2,2,2-trifluoroacetamide (3.5 g, 10.5 mmol) was added methanol (30 mL), followed by potassium carbonate (1.0 M 10.5 mL, 10.5 mmol). The reaction mixture was stirred for 30 min (Ref. Charifson, PS; et al. J. Med. Chem. 2008, 51, 5243-5263). Upon completion of the reaction, the reaction solution was diluted with deionized water and stirring was continued for 1 hour. The resulting orange solid was collected by filtration and dried in a vacuum oven to give the final target product 4-bromo-5-fluoro-2-nitroaniline (2.1 g, 8.8 mmol, 84% yield). | | References | [1] Patent: WO2012/83170, 2012, A1. Location in patent: Page/Page column 154-155
[2] Tetrahedron Letters, 2008, vol. 49, # 44, p. 6348 - 6351
[3] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 121
[4] Patent: US2007/259936, 2007, A1. Location in patent: Page/Page column 175 |
| | 4-Bromo-5-fluoro-2-nitroaniline Preparation Products And Raw materials |
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