|
ChemicalBook Optimization Suppliers |
| 名前: |
BOC Sciences |
| 電話番号: |
1-631-485-4226; 16314854226 |
| 電子メール: |
info@bocsci.com |
|
| 化学名: | サリノマイシン1-ナトリウム | | 英語化学名: | Salinomycin | | 别名: | SALINOMYCIN SODIUM SALT 2.5-HYDRATE;SALINOMYCIN SV SODIUM SALT 2,5-HYDRATE;Salinomycin hydrate monosodium salt;Salinomycin sodium premix;Salinomycin, monosodium salt;salinomycin monosodium salt hydrate;Salinomycin-Natrium;(2R)-2-[(5S,6R)-6-[(2S,3S,4S,6R)-6-[(2S,5R,7S,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid | | CAS番号: | 55721-31-8 | | 分子式: | C42H71NaO12 | | 分子量: | 791 | | EINECS: | 611-309-0 | | カテゴリ情報: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;S;SA - SM;Organics;Antibiotics;BactericidalAntibiotics;Chemical Structure;OthersAlphabetic;Principle | | Mol File: | 55721-31-8.mol |  |
| 融点 | 140-142° | | 比旋光度 | D25 -37° (c = 1 in ethanol) | | 貯蔵温度 | APPROX 4°C | | 溶解性 | Soluble in DMSO. | | 色 | White | | Merck | 13,8415 | | BRN | 4901827 | | 安定性： | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| 主な危険性 | T | | Rフレーズ | 25 | | Sフレーズ | 45 | | RIDADR | 2811 | | WGK Germany | 3 | | 国連危険物分類 | 6.1 | | 容器等級 | III |
| | サリノマイシン1-ナトリウム Usage And Synthesis |
| 説明 | Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5 | | 化学的特性 | Brown Solid | | 使用 | Salinomycin is an ionophore
agent. | | 使用 | Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells. | | 参考文献 | 1) Gupta?et al. (2009),?Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell,?138?645
2) Manago?et al. (2015),?Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis.,?6?e1930
3) Fu?et al. (2016),?Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway;?Oncol. Rep.,?35?912
4)?Kim?et al.?(2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin;?Mol. Med. Rep.,?12(2)?1898
5) Mai et al. (2017)?Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem.,?9?1025 |
|