钙抑肽
中文名称 | 钙抑肽 |
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中文同义词 | KATACALCIN肽;钙抑肽;抗钙素 TFA;卡他钙素;钙抑肽 KATACALCIN;卡他钙素 TFA盐 |
英文名称 | KATACALCIN |
英文同义词 | KATACALCIN;KATACALCIN (HUMAN);C-PROCALCITONIN;C-PROCALCITONIN (HUMAN);CALCITONIN C-TERMINAL FLANKING PEPTIDE (HUMAN);DMSSDLERDHRPHVSMPQNAN;H-ASP-MET-SER-SER-ASP-LEU-GLU-ARG-ASP-HIS-ARG-PRO-HIS-VAL-SER-MET-PRO-GLN-ASN-ALA-ASN-OH;ASP-MET-SER-SER-ASP-LEU-GLU-ARG-ASP-HIS-ARG-PRO-HIS-VAL-SER-MET-PRO-GLN-ASN-ALA-ASN |
CAS号 | 85916-47-8 |
分子式 | C97H154N34O36S2 |
分子量 | 2436.62 |
EINECS号 | |
相关类别 | 多肽;Peptide |
Mol文件 | 85916-47-8.mol |
结构式 |
钙抑肽 性质
密度 | 1.62±0.1 g/cm3(Predicted) |
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储存条件 | -15°C |
Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14 + peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14 + PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14 + PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14 + PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways.