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ChemStrong Scientific Co.,Ltd
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0755-0755-66853366 13670046396 |
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sales@chem-strong.com |
| Products Intro: |
Product Name:Teicoplanin A3-1
CAS:93616-27-4
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:Teicoplanin A3-1
CAS:93616-27-4
Purity:>98% by HPLC
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| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
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info@lynnchem.com |
| Products Intro: |
Product Name:Teicoplanin A3-1
CAS:93616-27-4
Purity:>98% by HPLC Package:1mg;5mg
|
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| | Teicoplanin A3-1 Basic information |
| Product Name: | Teicoplanin A3-1 | | Synonyms: | Teicoplanin A3-1;L 17054;Teicoplanin A3-1
DISCONTINUED. Please see T015500;Ristomycin A aglycone, 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-α-D-mannopyranosyl-;34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-α-D-mannopyranosyl-ristomycinAaglycone | | CAS: | 93616-27-4 | | MF: | C72H68Cl2N8O28 | | MW: | 1564.25 | | EINECS: | | | Product Categories: | | | Mol File: | 93616-27-4.mol |  |
| | Teicoplanin A3-1 Chemical Properties |
| density | 1.80±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide | | form | solid | | pka | 2.88±0.40(Predicted) |
| | Teicoplanin A3-1 Usage And Synthesis |
| Uses | Teicoplanin A3-1 is an antibiotic against Gram positive bacteria. | | Uses | Teicoplanin A3-1 is a minor polar analogue of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus. Teicoplanins possess potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. Teicoplanin A3-1 is the common degradation product of teicoplanins A2-1 to 5, resulting from cleavage of the lipoaminoglycoside substituents. | | Definition | ChEBI: A glycopeptide consisting of a macropolycyclic heptapeptide in which a phenolic hydroxy group has been converted to its alpha-D-mannoside while a secondary alcohol group has been converted to the corresponding 2-acetamido-
-deoxy-beta-D-glucoside. | | Biological Activity | teicoplanin a3-1, also known as antibiotic l 17054, is a glycopeptide antibiotic derived from actinoplanes teichomyceticus and produces a potent broad spectrum antibiotic activity against gram-positive bacteria.teicoplanin a3-1 is a common degradation product of teicoplanins a2-1 to 5, which results from cleavage of the lipoaminoglycoside substituents. teicoplanins are glycopeptide antibiotics produced by a. teichomyceticus which are effective against gram-positive bacteria, including methicillin-resistant staphylococcus aureus (mrsa) and e. faecalis. as an antibiotic complex, teicoplanin consists of five closely related factors, t-a2-1, 2, 3, 4 and 5 and a more polar factor, t-a3-1. additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in bacillus subtilis, which is accompanied by an intracellular accumulation of udp-n-acetylmuramyl-pentapetide [1]. due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci and staphylococci, including enterococci [2]. | | references | [1]. somma, s., gastaldo, l., & corti, a. teicoplanin, a new antibiotic from actinoplanes teichomyceticus nov. sp. antimicrobial agents and chemotherapy. 1984; 26(6): 917-923.
[2]. traina, g., & bonati, m. pharmacokinetics of teicoplanin in man after intravenous administration. journal of pharmacokinetics and biopharmaceutics. 1984;12(2): 119-128. |
| | Teicoplanin A3-1 Preparation Products And Raw materials |
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