- EPTAPIRONE
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- $1.00 / 1KG
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2019-12-26
- CAS:179756-58-2
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | EPTAPIRONE Basic information |
| Product Name: | EPTAPIRONE | | Synonyms: | EPTAPIRONE;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;F 11440;4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;F-11440;F11440;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Eptapirone(F11440);Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440 | | CAS: | 179756-58-2 | | MF: | C16H23N7O2 | | MW: | 345.4 | | EINECS: | | | Product Categories: | | | Mol File: | 179756-58-2.mol |  |
| | EPTAPIRONE Chemical Properties |
| Boiling point | 517.4±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF:10.0(Max Conc. mg/mL);28.95(Max Conc. mM) | | form | A crystalline solid | | pka | 7.72±0.10(Predicted) |
| | EPTAPIRONE Usage And Synthesis |
| Description | Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay). It is selective for 5-HT1A over other 5-HT receptor subtypes, dopamine D2 receptors, α1-adrenergic receptors, and histamine H1 receptors (Kis = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin in HA7 cells transfected with human 5-HT1A receptors (EC50 = 158 nM). In vivo, eptapirone increases extracellular 5-HT in the ventral hippocampus of rats (ED50 = 0.049 mg/kg) and serum corticosterone levels when administered p.o. or i.p. (ED50s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine in rats with no effect on sibutramine-induced hypophagia. | | Uses | Eptapirone is 5-HT1A receptor agonist with anxiolytic and antidepressant potential. | | Definition | ChEBI: Eptapirone is a N-arylpiperazine. |
| | EPTAPIRONE Preparation Products And Raw materials |
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