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| Product Name: | 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one | | Synonyms: | 3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone;Apixaban Intermediate3;5-morpholin-4-yl-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;3-(Morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one (Nitro MPDP);3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one;5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridi...;Apixaban intermediates，5,6-Dihydro-3-(4-morpholinyl)-1-(4- nitrophenyl)-2(1H)-pyridinone;2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)- | | CAS: | 503615-03-0 | | MF: | C15H17N3O4 | | MW: | 303.31 | | EINECS: | 123-548-3 | | Product Categories: | 503615-03-0 | | Mol File: | 503615-03-0.mol |  |
| | 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties |
| Boiling point | 506.5±50.0 °C(Predicted) | | density | 1.356 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 3.11±0.20(Predicted) | | color | Light Yellow | | InChI | InChI=1S/C15H17N3O4/c19-15-14(16-8-10-22-11-9-16)2-1-7-17(15)12-3-5-13(6-4-12)18(20)21/h2-6H,1,7-11H2 | | InChIKey | LBFAEOWNWSDWRZ-UHFFFAOYSA-N | | SMILES | C1(=O)N(C2=CC=C([N+]([O-])=O)C=C2)CCC=C1N1CCOCC1 |
| | 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Usage And Synthesis |
| Description | 3-(4-Morpholinyl)-1-(4-nitrophenyl)-5, 6-dihydro-2(1H)-pyridinone is the intermediate for the synthesis of apixaban, which is an anticoagulant for the treatment of venous thromboembolic events.
| | References | Chao, H. E., et al. "Synthesis of Apixaban." Chinese Journal of Pharmaceuticals (2014).
https://en.wikipedia.org/wiki/Apixaban
| | Uses | 3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one is a reagent in the synthesis of 4,5-dehydro Apixaban (D229385) an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation |
| | 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials |
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