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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid

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Company Name: 9i LLC
Tel: +18039569191
Email: MWan@NiNeiLab.com
Products Intro: Product Name:5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
CAS:437655-95-3
Purity:min.97% Package:225USD/1 g Remarks:NA932
Company Name: Chengdu Pukang Biotechnology Co., Ltd
Tel: 028-82550498
Email: export@pu-kang.com
Products Intro: Product Name:Fmoc-PEG4- CH2COOH
CAS:437655-95-3
Purity:95.0% Package:1 g;USD
Company Name: Changzhou Ditong Chemical Co.,Ltd
Tel: +86-0519-88299272
Email: info@edengenechem.com
Products Intro: Product Name:Fmoc-PEG4- CH2COOH
CAS:437655-95-3
Purity:0.98 Package:1kg;5kg;25kg
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Products Intro: Product Name:5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
CAS:437655-95-3
Package:1kg，2kg，5kg，10kg，25kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
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Products Intro: Product Name:5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
CAS:437655-95-3
Purity:99% Package:1KG;1USD

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid manufacturers
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Basic information
Product Name:5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
Synonyms:1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid;Fmoc-NH-PEG5-CH2CO2H;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid;FMoc-NH-PEG4-CH2COOH;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG4-CH2CO2H;Fmoc-PEG4- CH2COOH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
CAS:437655-95-3
MF:C25H31NO8
MW:473.52
EINECS:
Product Categories:peg
Mol File:437655-95-3.mol
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Structure
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Chemical Properties
Melting point 51℃
Boiling point 681.3±55.0 °C(Predicted)
density 1.235±0.06 g/cm3(Predicted)
storage temp. 2-8°C
form Oil
pka3.39±0.10(Predicted)
Safety Information
HS Code 2942000090
MSDS Information
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Usage And Synthesis
DescriptionFmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological ActivityFmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Cleavable

Alkyl/ether

PEGs

5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Preparation Products And Raw materials
Tag:5,8,11,14-Tetraoxa-2-azahexadecanedioic acid(437655-95-3) Related Product Information
N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE Succinimidyl 6-(biotinamido)hexanoate 2-[2-(2-methoxyethoxy)ethoxy]ethylamine H2N-PEG4-tBu OCTAETHYLENE GLYCOL MONOMETHYL ETHER 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE Maleimide-PEG4-NHS Ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol) Hexaethylene glycol 2,5,8,11-TETRAOXATRIDECANE-13-THIOL FMoc-NH-5(ethylene glycol)-acetic acid HO-PEG12-tBu N3-PEG4-tBu HEPTAETHYLENE GLYCOL MONOMETHYL ETHER FmocNH-PEG4-t-butyl acetate FmocNH-PEG5-t-butly ester FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID