| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Latanoprost free acid-d4
CAS:1224443-47-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Henan Vcommend Consultrading Co., Ltd.
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| Tel: |
13393721940 |
| Email: |
sales@vcommend.com |
| Products Intro: |
Product Name:Latanoprost EP Impurity H-d4 (Latanoprost USP Related Compound E-d4)
CAS:1224443-47-3
Purity:95.0% Package:10mg;20mg;50mg
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| | Latanoprost (free acid)-d4 Basic information |
| Product Name: | Latanoprost (free acid)-d4 | | Synonyms: | Latanoprost (free acid)-d4;HNPFPERDNWXAGS-GPPKKVIBSA-N;Latanoprost Acid-d4;[2H4]-Latanoprost Acid;Latanoprost EP Impurity H-d4 (Latanoprost USP Related Compound E-d4) | | CAS: | 1224443-47-3 | | MF: | C23H30D4O5 | | MW: | 394.537707112 | | EINECS: | | | Product Categories: | | | Mol File: | 1224443-47-3.mol |  |
| | Latanoprost (free acid)-d4 Chemical Properties |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Oil to Gel | | color | Colorless. |
| | Latanoprost (free acid)-d4 Usage And Synthesis |
| Description | Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. It is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2α and more than 200 times more potent latanoprost. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients. | | Uses | Latanoprost Acid-d4 is the labeled analogue of Latanoprost Acid (L177310), a metabolite of Latanoprost. Latanoprost Acid (L177310) is a potent, selective FP prostanoid receptor agonist, a F-series Prostaglandin analog and is 200 times as potent as isopropyl ester form. | | Definition | ChEBI: Latanoprost (free acid)-d4 is a prostanoid. |
| | Latanoprost (free acid)-d4 Preparation Products And Raw materials |
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