2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol

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2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol manufacturers

2-(1-(2-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)piperidin-2-yl)ethanol
$1.00
2025-02-13
CAS:841253-81-4
Min. Order: 1g
Purity: 0.98
Supply Ability: 1000

2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol Basic information

Product Name:	2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol
Synonyms:	2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol;2-Piperidineethanol, 1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-;CMPPE
CAS:	841253-81-4
MF:	C20H23ClN4O
MW:	370.88
EINECS:
Product Categories:
Mol File:	841253-81-4.mol

2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol Chemical Properties

storage temp.	2-8°C
solubility	DMSO: 5mg/mL, clear (warmed)
form	powder
color	white to light brown
InChI	1S/C20H23ClN4O/c1-14-12-20(24-10-3-2-4-17(24)9-11-26)25-19(22-14)13-18(23-25)15-5-7-16(21)8-6-15/h5-8,12-13,17,26H,2-4,9-11H2,1H3
InChIKey	TZWSGOPCLUTFBZ-UHFFFAOYSA-N
SMILES	ClC(C=C1)=CC=C1C2=NN(C(N3C(CCO)CCCC3)=CC(C)=N4)C4=C2

Safety Information

MSDS Information

2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol Usage And Synthesis

Uses	CMPPE is a GABAB receptor positive allosteric modulator (PAM) that inhibits alcohol self-administration and reinstatement behavior in rats[1].
Biological Activity	CMPPE is a GABAB receptor positive allosteric modulator (PAM). GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to mudulate GABA release and regulate K+ channels and Ca++ channels. CMPPE has the highest hypoactivity/anticonvulsant ratio.
References	[1] Paola Maccioni, et al. Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats. Alcohol. 2019 Mar:75:79-87. DOI:10.1016/j.alcohol.2018.05.015

2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol Preparation Products And Raw materials

Tag:2-(1-(2-(4-chlorophenyl)-5-Methylpyrazolo[1,5-a]pyriMidin-7-yl)piperidin-2-yl)ethanol(841253-81-4) Related Product Information

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