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| | LUZINDOLE Basic information |
| Product Name: | LUZINDOLE | | Synonyms: | LUZINDOLE;n-[2-[2-(phenylmethyl)-1h-indol-3-yl]ethyl]acetamide;N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide, N-Acetyl-2-benzyltryptamine;N-ACETYL-2-BENZYLTRYPTAMINE;N-0774;LuzindoleN-Acetyl-2-benzyltryptamine;N-(2-(2-benzyl-1H-indol-3-yl)ethyl)acetamide;2-Benzyl-N-acetyltryptaMine | | CAS: | 117946-91-5 | | MF: | C19H20N2O | | MW: | 292.37 | | EINECS: | | | Product Categories: | Melatonin receptor;Aromatics Compounds;Aromatics | | Mol File: | 117946-91-5.mol |  |
| | LUZINDOLE Chemical Properties |
| Melting point | 44-46°C | | Boiling point | 434.31°C (rough estimate) | | density | 1.1045 (rough estimate) | | refractive index | 1.6140 (estimate) | | storage temp. | -20°C | | solubility | DMSO: 5 mg/mL | | form | White to off-white crystalline solid. | | pka | 16.36±0.46(Predicted) | | color | Off-White to Yellow | | Water Solubility | Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water. | | Stability: | Store at -20°C | | CAS DataBase Reference | 117946-91-5(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | AC7765700 | | HS Code | 29339980 |
| | LUZINDOLE Usage And Synthesis |
| Chemical Properties | Off-White Amorphous Solid | | Uses | A melatonin receptor antagonist | | Uses | Luzindole significantly antagonizes melatonin-mediated antinociception, suggesting that MEL-1B-R plays a further role as a mediator of melatonin modulation of pain signaling. It is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response | | Definition | ChEBI: A member of the class of indoles that is tryptamine in which one of the amino hydrogens is replaced by an acetyl group while the hydrogen at position 2 is replaced by a benzyl group. | | Biological Activity | Melatonin antagonist. | | Biochem/physiol Actions | Luzindole is a melatonin (mel) receptor antagonist. It has higher affinity towards the Mel 1b receptor than the Mel 1a receptor subtype. | | storage | Store at -20°C |
| | LUZINDOLE Preparation Products And Raw materials |
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