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| 化学名: | ブセレリン | | 英語化学名: | BUSERELIN | | 别名: | (d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide;(d-ser(tbu)(sup6)-ea(sup10))-lhrh;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone;BUSERELIN;1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-;Buserilin;BUSERELIN PH. EUR. | | CAS番号: | 57982-77-1 | | 分子式: | C60H86N16O13 | | 分子量: | 1239.42 | | EINECS: | 261-061-9 | | カテゴリ情報: | 57982-77-1;hormones | | Mol File: | 57982-77-1.mol |  |
| 比旋光度 | D20 -40.4° (c = 1 in dimethylacetamide) | | 沸点 | 845.19°C (rough estimate) | | 比重(密度) | 1.0711 (rough estimate) | | 屈折率 | 1.6200 (estimate) | | 溶解性 | Sparingly soluble in water and in dilute acids. | | 酸解離定数(Pka) | 9.82±0.15(Predicted) | | 外見 | Solid | | 色 | White to Off-White | | 安定性： | Hygroscopic | | InChIKey | CUWODFFVMXJOKD-UHFFFAOYSA-N |
| | ブセレリン Usage And Synthesis |
| 効能 | 子宮内膜症治療薬, 性腺刺激ホルモン放出ホルモン受容体作動薬 | | 説明 | Buserelin (Suprefact?) is a hormonal therapy drug used to treat advanced prostate cancer. It is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat. | | 化学的特性 | White or slightly yellowish powder, hygroscopic. | | 使用 | Gonad-stimulating principle. | | 定義 | ChEBI: Buserelin is an oligopeptide. | | brand name | Suprefact
(Hoechst-Roussel). | | 臨床応用 |
Treatment of advanced prostate cancer and
endometriosis
Pituitary desensitisation in preparation for ovulation
induction regimens using gonadotrophins | | 副作用 | Using too much Buserelin Injection may make you feel weak, nervous, dizzy and sick. You may also have a headache, hot flushes, stomach pain, swelling of the legs and breast pain. You may also have pain, bleeding or hardening of the skin at the site of injection | | 代謝 | Metabolic inactivation by peptides occurs in the liver
and kidney. The drug is also inactivated by pituitary
membrane enzymes.
Excreted in the urine and bile as unchanged drug and
metabolites. |
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