| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:ML-031
CAS:852230-33-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:ML-031;cancer,LPL Receptor,Inhibitor,ML031,inhibit,S1PR2,CYM-5482,CYM 5482,CYM5482,Lysophospholipid Receptor,ML 031
CAS:852230-33-2
Purity:98.29% Package:1 mg;10 mg;100 mg;2 mg;25 mg;5 mg;50 mg
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| Product Name: | ML-031 | | Synonyms: | ML-031;1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione;CYM-5482;cancer,LPL Receptor,Inhibitor,ML031,inhibit,S1PR2,CYM-5482,CYM 5482,CYM5482,Lysophospholipid Receptor,ML 031;2,5-Pyrrolidinedione, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]- | | CAS: | 852230-33-2 | | MF: | C19H20N2O3 | | MW: | 324.3737 | | EINECS: | | | Product Categories: | | | Mol File: | 852230-33-2.mol |  |
| | ML-031 Chemical Properties |
| Boiling point | 568.8±50.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤5mg/ml in ethanol;5mg/ml in DMSO | | form | crystalline solid | | pka | -1.75±0.20(Predicted) |
| | ML-031 Usage And Synthesis |
| Definition | ChEBI: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-oxoethyl]pyrrolidine-2,5-dione is an aromatic ketone. | | Biological Activity | ml-031 is an agonist of s1p2 with ec50 value of 1 μm [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. sphingolipids belong to a family of bioactive molecules with cell signaling properties. sphingosine 1-phosphate (s1p) is widely expressed on various tissues and cell types. s1p is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. until now, five sphingosine-1-phosphate receptors (s1pr1-s1pr5) have been identified. s1pr4 and s1pr5 are prominently expressed in the immune and nervous systems, respectively. s1p functions by binding to five distinct g protein-coupled receptors, s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8.ml-031 activated s1p2 with an ec50 value of 1 μm in a s1p reporter assay [1]. | | references | [1] satsu h, schaeffer m t, guerrero m, et al. a sphingosine 1-phosphate receptor 2 selective allosteric agonist[j]. bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382. |
| | ML-031 Preparation Products And Raw materials |
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