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ChemicalBook Optimization Suppliers |
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| | 4,5,6,7-テトラクロロ-1,3-インダンジオン 製品概要 |
| 化学名: | 4,5,6,7-テトラクロロ-1,3-インダンジオン | | 英語化学名: | TCID | | 别名: | 4,5,6,7-TETRACHLOROINDAN-1,3-DIONE;4,5,6,7-TETRACHLOROINDANE-1,3-DIONE;4,5,6,7-TETRACHLORO-1H-INDENE-1,3(2H)-DIONE;4,5,6,7-Tetrachloro-1,3-indanedione;4,5,6,7-Tetrachloroindane-1,3-dione 95+%;4,5,6,7-tetrachloro-2,3-dihydro-1H-indene-1,3-dione;TCID;1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro- | | CAS番号: | 30675-13-9 | | 分子式: | C9H2Cl4O2 | | 分子量: | 283.92 | | EINECS: | | | カテゴリ情報: | Inhibitors | | Mol File: | 30675-13-9.mol |  |
| | 4,5,6,7-テトラクロロ-1,3-インダンジオン 物理性質 |
| 融点 | 218-220 | | 沸点 | 448.1±45.0 °C(Predicted) | | 比重(密度) | 1.782±0.06 g/cm3(Predicted) | | 貯蔵温度 | +2C to +8C | | 溶解性 | Soluble in DMSO (up to 25 mg/ml), | | 外見 | Orange solid | | 酸解離定数(Pka) | 8.62±0.20(Predicted) | | 色 | White | | 安定性： | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| 主な危険性 | Xi | | Hazard Note | Irritant |
| | 4,5,6,7-テトラクロロ-1,3-インダンジオン Usage And Synthesis |
| 説明 | TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable. | | 使用 | TCID is a small molecule inhibitor of DNA polymerase λ. | | 貯蔵 | Store at -20°C | | 参考文献 | 1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697
2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022 |
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