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| 融点 | 129-131.5 °C (lit.) | | 沸点 | 331.88°C (rough estimate) | | 比旋光度 | -16.5 º (c=10, H2O, on dry sub) | | 比重(密度) | 1.2669 (rough estimate) | | RTECS 番号 | LZ4295770 | | 屈折率 | -16.5 ° (C=2, H2O) | | 貯蔵温度 | 2-8°C | | 溶解性 | H2O: 0.1 g/mL, clear, colorless | | 外見 | Crystalline Powder | | 酸解離定数(Pka) | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) | | 色 | White to almost white | | PH | 11 (10g/l, H2O, 20℃) | | 光学活性 (optical activity) | [α]20/D 16.5±0.5°, c = 2% in H2O | | 水溶解度 | 100 g/100 mL (25 ºC) | | Sensitive | Air Sensitive & Hygroscopic | | Merck | 14,6078 | | BRN | 385906 | | InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N | | LogP | -3.370 (est) | | NISTの化学物質情報 | N-methylglucamine(6284-40-8) | | EPAの化学物質情報 | Meglumine (6284-40-8) |
| Rフレーズ | 36/37/38 | | Sフレーズ | 24/25 | | WGK Germany | 3 | | F | 3-10-23 | | 自然発火温度 | ~662 °F | | TSCA | Yes | | HSコード | 29221980 | | 毒性 | LD50 orally in Rabbit: > 5000 mg/kg |
| | N-メチル-D-グルカミン Usage And Synthesis |
| 外観 | 白色～ほとんど白色, 結晶性粉末～粉末又は塊 | | 定義 | 本品は、次の化学式で表される有機化合物である。 | | 溶解性 | 水に易溶、メタノール, エタノールに難溶、クロロホルム, エーテルに不溶。 | | 用途 | イオン交換、キレート樹脂原料。有機合成原料。 | | 化粧品の成分用途 | pH調整剤 | | 効能 | 診断補助薬 (放射線不透過性造影剤) | | 化学的特性 | white to almost white crystalline powder | | 化学的特性 | Meglumine occurs as a white to slightly yellow-colored crystalline
powder; it is odorless or with a slight odor. | | 使用 | N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes. | | 使用 | antiinflammatory | | 使用 | excipient in cosmetics and X-ray contrast media | | 調製方法 | Meglumine is prepared by the imination of glucose and monomethylamine,
in an alcoholic solution, followed by catalytic
hydrogenation. | | 定義 | ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi
e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. | | brand name | Renovue
(Bracco). | | 一般的な説明 | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations. | | 応用例（製薬） | Meglumine is an organic base used as a pH-adjusting agent and
solubilizing agent, primarily in the preparation of soluble salts of
iodinated organic acids used as X-ray contrast media. | | 安全性 | Meglumine is widely used in parenteral pharmaceutical formulations
and is generally regarded as a nontoxic material at the levels
usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg | | 貯蔵 | Meglumine does not polymerize or dehydrate unless heated above
150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a
cool, dry place. Meglumine should not be stored in aluminum
containers since it reacts to evolve hydrogen gas; it discolors if
stored in containers made from copper or copper alloys. Stainless
steel containers are recommended. | | 純化方法 | Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] | | 不和合性 | Incompatible with aluminum, copper, mineral acids, and oxidizing
materials. Differential scanning calorimetry studies suggest meglumine
is incompatible with glipizide. | | 規制状況(Regulatory Status) | Included in the FDA Inactive Ingredients Database (injections; oral
tablets). Included in parenteral medicines licensed in the UK. |
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