可的松
中文名称 | 可的松 |
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中文同义词 | 皮质酮/可的松;可的松-D2;甲醇中可的松溶液标准物质;11-去氢-17-羟皮质甾酮;17-羟-11-脱皮质酮;17-羟-11脱氢皮质酮;可的松;肾上腺皮质激素 |
英文名称 | CORTISONE |
英文同义词 | 17ALPHA,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE;17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE;17ALPHA-HYDROXY-11-DEHYDROCORTICOSTERONE;17-HYDROXY-11-DEHYDROCORTICOSTERONE;4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE;4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE;4-PREGNEN-17,21-DIOL-3,11,20-TRIONE;4-PREGEN-17A,21-DIOL-3,11,20-TRIONE |
CAS号 | 53-06-5 |
分子式 | C21H28O5 |
分子量 | 360.44 |
EINECS号 | 200-162-4 |
相关类别 | 甾体激素 (激素,糖皮激素);甾体激素类;医药原料药;脂类;小分子抑制剂;小分子抑制剂,天然产物;Biochemistry;激素;生化试剂;生物化学品;对照品;标准品 -中药标准品;医药原料;医用原料;通用生化试剂-天然产物;原料药;化学试剂;临床检测标准物质;Steroids;Hydroxyketosteroids;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitors |
Mol文件 | 53-06-5.mol |
结构式 |
可的松 性质
熔点 | 223-228 °C (dec.)(lit.) |
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比旋光度 | D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol) |
沸点 | 412.46°C (rough estimate) |
密度 | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
折射率 | 210 ° (C=1, EtOH) |
闪点 | 9℃ |
储存条件 | -20°C Freezer |
溶解度 | 氯仿(轻微溶解、加热、超声处理)、DMSO(轻微溶解)、乙醇(轻微溶解、加热) |
形态 | 固体 |
酸度系数(pKa) | 12.37±0.60(Predicted) |
颜色 | 白色至浅棕色 |
水溶解性 | 229.9mg/L(25 ºC) |
Merck | 2539 |
LogP | 1.470 |
CAS 数据库 | 53-06-5(CAS DataBase Reference) |
可的松主要用于肾上腺皮质功能减退症的替代治疗,但现在氢化可的松已优先用于此症。因为可的松本身无活性,必需先在肝内转化成氢化可的松,某些肝脏疾病将影响其作用的可靠性。
Cortisone是一种孕烷甾类激素,是身体应对压力应激时释放的主要物质。它能抑制免疫系统,从而减少炎症反应和炎性疼痛、伤处肿胀。
Human Endogenous Metabolite
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Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).
Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.
Animal Model: | Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion |
Dosage: | 2 mg/kg |
Administration: | Intramuscular injection on alternate days for 2 months |
Result: |
Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive. |
安全信息
危险品标志 | F,T,Xn |
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危险类别码 | 11-23/24/25-39/23/24/25-63 |
安全说明 | 22-24/25-45-36/37-16-7 |
危险品运输编号 | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS号 | GM9020000 |
F | 18 |
海关编码 | 2937210000 |
提供商 | 语言 |
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英文
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