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53-06-5

中文名称 可的松
英文名称 CORTISONE
CAS 53-06-5
EINECS 编号 200-162-4
分子式 C21H28O5
MDL 编号 MFCD00003610
分子量 360.44
MOL 文件 53-06-5.mol
更新日期 2024/03/11 11:58:42
53-06-5 结构式 53-06-5 结构式

基本信息

中文别名
17-羟-11脱氢皮质(甾)酮
可的松
肾上腺皮质激素
11-去氢-17-羟基皮质酮
17-羟-11-脱皮质(甾)酮
11-去氫-17-羥皮質甾酮
可體松
皮質酮
17Α,21-二羥-4-孕烯-3,11,20-三酮
11-去氢-17-羟基皮质酮,11-DEHYDRO-17-HYDROXYCORTICOSTERONE
17Α,21-二羟基-4-孕甾烯-2,11,20-三酮,17Α,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
英文别名
11-DEHYDRO-17-HYDROXYCORTICOSTERONE
17A 21-DIHYDROXY-4-PREGNEN-3 17 20-TRIONE
17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
17ALPHA,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE
17ALPHA-HYDROXY-11-DEHYDROCORTICOSTERONE
17-HYDROXY-11-DEHYDROCORTICOSTERONE
4-PREGEN-17A,21-DIOL-3,11,20-TRIONE
4-PREGNEN-17,21-DIOL-3,11,20-TRIONE
4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE
4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
CORTISONE
CORTONE
DELTA4-PREGNENE-17, 21-DIOL-3, 11, 20-TRIONE
DELTA4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
DELTA-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
KENDALL'S CMPD ''E''
KENDALL'S COMPOUND E
KENDALL'S COMPOUND 'E'
KENDALL'S ''E''
REICHSTEIN'S COMPOUND ''FA''
所属类别
生物化学品: 生化试剂: 激素

物理化学性质

外观性状白色结晶性粉末。Mp220-224℃(部分分解),比旋光度[α]25D+209°(1.2%,95%乙醇)、[α]25546+269°(0.125%,苯)。溶于甲醇、乙醇、丙酮;微溶于乙醚、氯仿和苯;难溶于水,水溶液呈中性。在浓硫酸中呈橙红色,并显绿色荧光。
熔点223-228 °C (dec.)(lit.)
比旋光度D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
沸点412.46°C (rough estimate)
密度1.28±0.1 g/cm3 (20 ºC 760 Torr)
折射率210 ° (C=1, EtOH)
闪点9℃
储存条件-20°C冷冻
溶解度Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Ethanol (Slightly, Heated)
酸度系数(pKa)12.37±0.60(Predicted)
形态固体
颜色白色至浅米色
水溶解性229.9mg/L(25 ºC)
Merck2539
LogP1.470

安全数据

危险性符号(GHS)
GHS02,GHS06,GHS08
警示词危险
危险品标志F,T,Xn
安全说明S22-S24/25
危险品运输编号UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS号GM9020000
海关编码2937210000

应用领域

用途一
生化研究;皮质激素类药物,具有抗炎、抗过敏等作用。
参考质量标准
mp215-225℃;比旋光度+207°;最大吸收波长238nm。

制备方法

方法一
以醋酸孕甾双烯醇酮为原料,依次经过氧化氢氧化、沃氏氧化、黑根菌生物氧化、铬酐氧化得11-酮基-16,17α环氧黄体酮,经氢溴酸开环,氢化脱溴得粗品,再重结晶制得。

常见问题列表

应用

可的松主要用于肾上腺皮质功能减退症的替代治疗,但现在氢化可的松已优先用于此症。因为可的松本身无活性,必需先在肝内转化成氢化可的松,某些肝脏疾病将影响其作用的可靠性。

生物活性
Cortisone是一种孕烷甾类激素,是身体应对压力应激时释放的主要物质。它能抑制免疫系统,从而减少炎症反应和炎性疼痛、伤处肿胀。
靶点

Human Endogenous Metabolite

体外研究

Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).

体内研究

Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.

Animal Model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion
Dosage: 2 mg/kg
Administration: Intramuscular injection on alternate days for 2 months
Result: Reduced the BCG lesions and tuberculin reactions.
Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.

知名试剂公司产品信息

可的松价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-17461可的松
Cortisone
53-06-5100mg600元
2024/01/25HY-17461可的松
Cortisone
53-06-510mM * 1mLin DMSO660元
2024/01/25HY-17461可的松
Cortisone
53-06-5500mg1000元
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