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| | Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-フルオロメチルケトン 製品概要 |
| 化学名: | Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-フルオロメチルケトン | | 英語化学名: | Z-DEVD-FMK | | 别名: | Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK;Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE;Z-DEVD-FLUOROMETHYLKETONE;Z-DEVD-FMK;Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE | | CAS番号: | 210344-95-9 | | 分子式: | C30H41FN4O12 | | 分子量: | 668.66 | | EINECS: | | | カテゴリ情報: | Inhibitors;Apoptosis;peptides;API;Caspases/Apoptosis;peptide;Caspase/Related Products;Pepetides | | Mol File: | Mol File |  |
| | Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-フルオロメチルケトン 物理性質 |
| 沸点 | 914.2±65.0 °C(Predicted) | | 比重(密度) | 1.260±0.06 g/cm3(Predicted) | | 貯蔵温度 | Inert atmosphere,Store in freezer, under -20°C | | 溶解性 | DMSO/DMF: ≥20 mM | | 酸解離定数(Pka) | 10.26±0.46(Predicted) | | 外見 | White to slightly brown solid |
| | Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-フルオロメチルケトン Usage And Synthesis |
| 使用 | Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage. | | 定義 | ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent. | | 一般的な説明 | A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available. | | 生物活性 | Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo . | | Biochem/physiol Actions | Cell permeable: yes | | target | Caspase-3 | | 参考文献 | 1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132. |
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