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ChemicalBook Optimization Suppliers |
| 名前: |
Kono Chem Co.,Ltd Gold |
| 電話番号: |
029-86107037-8009 13279399072 |
| 電子メール: |
info@konochemical.com |
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| 融点 | approximate 240℃ | | 比重(密度) | 1.782 g/cm3(Temp: 25 °C) | | 蒸気圧 | 0Pa at 25℃ | | 貯蔵温度 | Sealed in dry,Room Temperature | | 溶解性 | almost transparency in Pyridine | | 外見 | Powder | | 色 | White to Orange to Green | | 臭い (Odor) | Mild Characteristic | | 水溶解度 | Insoluble (<0.1 g/100 mL at 21 ºC) | | Merck | 14,7994 | | InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2 | | InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L | | SMILES | C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-] | | LogP | 0.9 at 25℃ and pH7.5-7.7 | | 表面張力 | 73mN/m at 7.22mg/L and 20℃ | | CAS データベース | 13463-41-7(CAS DataBase Reference) | | EPAの化学物質情報 | Zinc pyrithione (13463-41-7) |
| | ピリチオン亜鉛 Usage And Synthesis |
| 外観 | 白色～うすい褐色, 結晶性粉末～粉末又は塊 | | 定義 | 本品は、次の化学式で表される芳香族亜鉛化合物である。 | | 溶解性 | 塩酸に溶け、水にほとんど溶けない。 | | 用途 | 金属イオンの存在で錯化合物をつくり着色します.
工業用殺菌剤
| | 用途 | LC/MS・LC分析の標準品として使用 | | 用途 | ふけ防止シャンプー.農業用殺菌剤 防菌?防カビ?防藻剤 | | 化粧品の成分用途 | ヘアコンディショニング剤、防腐剤、抗フケ剤、殺菌剤 | | 効能 | 抗菌薬, 抗真菌薬, 脂漏性湿疹薬 | | 主な用途／役割 | ふけ防除剤、殺菌剤として用いられます。
| | 使用上の注意 | 光で分解されます。遮光保存して下さい。 | | 説明 | Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff. | | 化学的特性 | Beige granules | | 使用 | Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams. | | 使用 | zinc pyrithione is a preservative against bacteria, fungi, and yeast. It is unstable in light and in the presence of oxidizing agents. Zinc pyrithione is useful in gels, creams, heavy lotions, and talcum powder. | | 使用 | Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.
Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing. | | 適応症 | Zinc pyrithione is the active ingredient in several shampoos used to control
dandruff and seborrheic dermatitis and is also effective in the therapy of tinea
versicolor. It remains unclear whether the beneficial effects are caused by an
antiproliferative or antimicrobial effect or both. It is substantive to the hair,
allowing continued therapeutic effect after washing. | | brand name | Head & Shoulders Conditioner (Procter & Gamble). | | 一般的な説明 | Fine beige granules. | | 空気と水の反応 | Insoluble in water. | | 反応プロフィール | Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. | | 火災危険 | Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible. | | 接触アレルゲン | Zinc pyrithione is widely used in antidandruff
shampoos and is a classic allergen. Concomitant reactions
are expected to both zinc and sodium pyrithione. | | 安全性プロファイル | Poison by ingestion,
skin contact, intraperitoneal, and
intravenous routes. Moderately toxic by
subcutaneous route. An experimental
teratogen. Experimental reproductive
effects. An eye irritant. When heated to
decomposition it emits very toxic fumes of
NOx, SOx, and ZnO. Used as an anti-
dandruff agent in shampoos. See also ZINC
COMPOUNDS and SULFIDES. | | 合成 | 1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring. To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes. After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water. The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of zinc pyrithione. The zinc pyrithione thus obtained was 212 g with a yield of 99.5 %. |
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