利坦丝林
| 中文名称 | 利坦丝林 |
|---|---|
| 中文同义词 | 利坦丝林;利坦丝林 25MG;利坦色林;6-(2-(4-(双(4-氟苯基)亚甲基)哌啶-1-基)乙基)-7-甲基-5H-噻唑并[3,2-A]嘧啶-5-酮;利坦丝林,10 MM DMSO 溶液;【进口原装】87051-43-2利坦丝林;利坦色林 Ritanserin;【进口原装】87051-43-2利坦丝林 |
| 英文名称 | Ritanserin |
| 英文同义词 | 6-[2-[4-(bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one;RITANSERIN SEROTONIN ANTAGONIST;6-[2-[4-[Bis(4-fluorophenyl)methylene]-piperidino]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-one;6-[2-[4-[Bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one;6-[2-[4-[Bis(4-fluorophenyl)Methylidene]piperidin-1-yl]ethyl]-7-Methyl-[1,3]thia;Tiserton;6-[2-[4-[Bis(4-fluorophenyl)Methylidene]piperidin-1-yl]ethyl]-7-Methyl-[1,3]thiazolo[2,3-b]pyriMidin-5-one HCl;6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin |
| CAS号 | 87051-43-2 |
| 分子式 | C27H25F2N3OS |
| 分子量 | 477.57 |
| EINECS号 | |
| 相关类别 | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;Serotonin receptor |
| Mol文件 | 87051-43-2.mol |
| 结构式 |  |
利坦丝林 性质
| 熔点 | 145.5° |
|---|---|
| 沸点 | 618.7±65.0 °C(Predicted) |
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 在甲醇中可溶>10 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.74±0.20(Predicted) |
| 颜色 | 白色 |
| InChI | 1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
| InChIKey | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
| SMILES | CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1 |
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5-HT 2 Receptor 0.9 nM (IC 50 ) |
H 1 Receptor 35 nM (IC 50 ) |
D 2 Receptor 70 nM (IC 50 ) |
Adrenergic α1 97 nM (IC 50 ) |
Adrenergic α2 150 nM (IC 50 ) |
Ritanserin (R 55667) is a highly potent, relatively selective, long acting antagonist of 5-HT2 receptor, with an IC 50 of 0.9 nM, less active on Histamine-H 1 (IC 50 , 35 nM), Dopamine-D 2 (IC 50 , 70 nM), Adrenergic-α 1 (IC 50 , 97 nM), Adrenergic-α 2 receptor (IC 50 , 150 nM).
安全信息
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-10791R | 利坦丝林 Ritanserin (Standard) | 87051-43-2 | 5 mg | 2000元 |
| 2026/09/15 | HY-10791 | 利坦丝林 Ritanserin | 87051-43-2 | 1 mg | 396元 |