Endothelin-3 (human, rat) (trifluoroacetate salt)

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Endothelin-3 (human, rat) (trifluoroacetate salt) Basic information
Product Name:Endothelin-3 (human, rat) (trifluoroacetate salt)
Synonyms:Endothelin-3 (human, rat) (trifluoroacetate salt)
CAS:
MF:C121H168N26O33S4
MW:2643.04302
EINECS:
Product Categories:
Mol File:Mol File
Endothelin-3 (human, rat) (trifluoroacetate salt) Structure
Endothelin-3 (human, rat) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
Safety Information
MSDS Information
Endothelin-3 (human, rat) (trifluoroacetate salt) Usage And Synthesis
DescriptionEndothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively). It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively. It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB. Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.
References[1] JANET J. MAGUIRE . Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways[J]. Life sciences, 2012, 91 13: Pages 544-549. DOI: 10.1016/j.lfs.2012.03.021
[2] T X WATANABE. Effects of endothelin-1 and endothelin-3 on blood pressure in conscious hypertensive rats.[J]. Journal of Cardiovascular Pharmacology, 1989, 13 Suppl 5: S207-8. DOI: 10.1097/00005344-198900135-00059
[3] E. GAZQUEZ. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep37877
Endothelin-3 (human, rat) (trifluoroacetate salt) Preparation Products And Raw materials
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