| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:RP 001 hydrochloride
CAS:1781880-34-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | RP 001 (hydrochloride) Basic information |
| Product Name: | RP 001 (hydrochloride) | | Synonyms: | RP001 hydrochloride,RP 001 hydrochloride;N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine,monohydrochloride | | CAS: | 1781880-34-9 | | MF: | C24H25ClN4O4 | | MW: | 468.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1781880-34-9.mol |  |
| | RP 001 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 100 mM | | form | A solid |
| | RP 001 (hydrochloride) Usage And Synthesis |
| Description | RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 9 pM). It is competitive with W146 , a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis. | | Uses | RP 001 Hydrochloride is a picomolar, short-acting S1P1 agonist. | | storage | Store at -20°C |
| | RP 001 (hydrochloride) Preparation Products And Raw materials |
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