N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine
| 中文名称 | N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine |
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| 中文同义词 | N-[(1S)-1-(5-氟-2-嘧啶基)乙基]-3-[5-(1-甲基乙氧基)-1H-吡唑-3-基]-3H-咪唑并[4,5-B]吡啶-5-胺;化合物 AZD7451 |
| 英文名称 | N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine |
| 英文同义词 | N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine;AZD-7451;3H-Imidazo[4,5-b]pyridin-5-amine, N-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-3-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-;Utatrectinib;N-[(1S)-1-(5-Fluoro-2-pyrimidinyl)ethyl]-3-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-3H-imidazo[4,5-b]pyridin-5-amine (ACI) |
| CAS号 | 1079274-94-4 |
| 分子式 | C18H19FN8O |
| 分子量 | 382.39 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1079274-94-4.mol |
| 结构式 | ![N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine 结构式](CAS/20200401/GIF/1079274-94-4.gif) |
N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine 性质
| 沸点 | 645.9±65.0 °C(Predicted) |
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| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 10.78±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | Blue to blue-green |
N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-amine 用途与合成方法
Utatrectinib (AZD-7451) 是一种有效的、选择性的和具有口服活性的 Trk 抑制剂。Utatrectinib 可阻断 TrkC 激活和相关的致瘤行为。