- Cyclizine Hydrochloride
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- $15.00 / 1KG
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2021-07-02
- CAS:303-25-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Cyclizine Hydrochloride Basic information |
| | Cyclizine Hydrochloride Chemical Properties |
| Melting point | 258-260℃ | | Boiling point | 457.04°C (rough estimate) | | density | 1.0551 (rough estimate) | | refractive index | 1.5749 (estimate) | | storage temp. | Refrigerator | | solubility | Methanol: 1 mg/ml |
| Hazard Codes | T | | Risk Statements | 61-23/24/25-42/43 | | Safety Statements | 53-22-36/37/39-45 | | RIDADR | 3249 | | WGK Germany | 3 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2933595960 | | Toxicity | mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975. |
| | Cyclizine Hydrochloride Usage And Synthesis |
| Chemical Properties |
Off-White Solid
moderately soluble in water
| | Originator | Marezine,BurroughsWellcome,US,1953 | | Uses | Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness.
Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli | | Uses | Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic. | | Definition | ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine. | | Manufacturing Process | One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g)
of N-methylpiperazine and about 10 cc of benzene and the whole was heated
on the steam bath four hours. The contents of the flask was partitioned
between ether and water, and the ethereal layer was washed with water until
the washings were neutral. The base was then extracted from the ethereal
layer by N hydrochloric acid and the extract, made acid to Congo red paper,
was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by
recrystallization from 95% alcohol melting above 250°C with decomposition.
The addition of alkali to an aqueous solution of the dihydrochloride liberated
the base which was recovered by recrystallization from petroleum ether
melting at 105.5° to 107.5°C. | | Therapeutic Function | Antinauseant |
| | Cyclizine Hydrochloride Preparation Products And Raw materials |
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