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| OLPRINONE HYDROCHLORIDE Basic information |
Product Name: | OLPRINONE HYDROCHLORIDE | Synonyms: | 3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;e1020;xo-,monohydrochloride,monohydrate;OLPRINONE HCL;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;Coretec;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride | CAS: | 119615-63-3 | MF: | C14H11ClN4O | MW: | 286.72 | EINECS: | | Product Categories: | Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | Mol File: | 119615-63-3.mol | |
| OLPRINONE HYDROCHLORIDE Chemical Properties |
Melting point | >3000C | storage temp. | 2-8°C | solubility | DMSO: ≤4 mg/mL | form | solid | color | beige |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36 | WGK Germany | 2 | RTECS | US4201450 |
| OLPRINONE HYDROCHLORIDE Usage And Synthesis |
Description | Coatec was launched in Japan for acute cardiac insufficiency in cases
resistant to other treatments. There are three related synthetic routes, 5-6 steps
each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an
advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long
lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused
increased levels of CAMP which leads to the positive inotropic effect that was not
altered by β or H2-preceptor antagonists. It was 100 times less potent at PDE I and
PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight
changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and
its primary metabolite was less active. | Chemical Properties | Off-White Crystalline Powder | Originator | Eisai (Japan) | Uses | Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic. | Definition | ChEBI: Olprinone hydrochloride is an organic molecular entity. | Brand name | Coatec |
| OLPRINONE HYDROCHLORIDE Preparation Products And Raw materials |
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