| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Rec 15/2615 (hydrochloride)
CAS:1782573-48-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Rec 15/2615 hydrochloride
CAS:1782573-48-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Rec 15/2615 (hydrochloride)
CAS:1782573-48-1
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
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Rec 15/2615 (hydrochloride) manufacturers
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| | Rec 15/2615 (hydrochloride) Basic information |
| Product Name: | Rec 15/2615 (hydrochloride) | | Synonyms: | Rec 15/2615 (hydrochloride);1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]-ethanone, dihydrochloride;Rec 15/2615 HCl | | CAS: | 1782573-48-1 | | MF: | C26H34ClN5O5 | | MW: | 532.04 | | EINECS: | | | Product Categories: | | | Mol File: | 1782573-48-1.mol |  |
| | Rec 15/2615 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 100 mM | | form | A solid |
| | Rec 15/2615 (hydrochloride) Usage And Synthesis |
| Biological Activity | Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM).2 It decreases diastolic blood pressure (ED25 = 183 μg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 μg/kg.1,2 | | References | |1. Sironi, G., Colombo, D., Poggesi, E., et al. Effects of intracavernous administration of selective antagonists of α1-adrenoceptor subtypes on erection in anesthetized rats and dogs. J. Pharmacol. Exp. Ther. 292(3), 974-981 (2000).|2. Testa, R., Guarneri, L., Angelico, P., et al. Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J. Pharmacol. Exp. Ther. 281(3), 1284-1293 (1997). |
| | Rec 15/2615 (hydrochloride) Preparation Products And Raw materials |
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