1-羟基蒽醌
| 中文名称 | 1-羟基蒽醌 |
|---|---|
| 中文同义词 | α-羟基蒽醌;1-羟基-9,10-蒽二酮;1-羟基蒽醌 5G;1-羥蒽醌;1-羟基蒽醌;蒽醌杂质9;1-羟蒽醌;Α-羟基蒽醌 |
| 英文名称 | 1-Hydroxy anthraquinone |
| 英文同义词 | 4-HYDROXYANTHRAQUINONE;1-hydroxy-9,10-anthracenedione;1-HYDROXYANTHRAQUINONE;erythroxyanthraquinone;1-hydroxyanthracene-9,10-dione;NISTC129431;10-Anthracenedione,1-hydroxy-9;1-hydroxy-10-anthracenedione |
| CAS号 | 129-43-1 |
| 分子式 | C14H8O3 |
| 分子量 | 224.21 |
| EINECS号 | 204-946-7 |
| 相关类别 | 标准品;通用试剂;酮;对照品;Anthraquinones;Hydroxyanthraquinones;Classes of Metal Compounds;Li (Lithium) Compounds;Typical Metal Compounds |
| Mol文件 | 129-43-1.mol |
| 结构式 |  |
1-羟基蒽醌 性质
| 熔点 | 194°C |
|---|---|
| 沸点 | 325.61°C (rough estimate) |
| 密度 | 1.2337 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 氯仿：30mg/mL |
| 形态 | 粉末晶体 |
| 酸度系数(pKa) | 7.15±0.20(Predicted) |
| 颜色 | 浅黄色至棕色 |
| CAS 数据库 | 129-43-1(CAS DataBase Reference) |
| (IARC)致癌物分类 | 2B (Vol. 82) 2002 |
| NIST化学物质信息 | 9,10-Anthracenedione, 1-hydroxy-(129-43-1) |
| EPA化学物质信息 | 9,10-Anthracenedione, 1-hydroxy- (129-43-1) |
1-Hydroxyanthraquinone 是具有口服活性的天然产物，可来源于一些植物如 Tabebuia avellanedae，具有致癌作用。
1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats.
| Animal Model: | Thirty rats. |
| Dosage: | 1% HA in diet. |
| Administration: | Diet. |
| Result: |
Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g). |
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 36/37/38-40-36 |
| 安全说明 | 26-36/37/39-45 |
| RTECS号 | CB7178000 |
| 海关编码 | 2914.69.9000 |
| 毒害物质数据 | 129-43-1(Hazardous Substances Data) |
| 提供商 | 语言 |
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英文
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