2-氨基-3-氯-1,4-萘醌
中文名称 | 2-氨基-3-氯-1,4-萘醌 |
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中文同义词 | 氨氯萘醌;2-氨基-3-氯-1,4-萘醌;灭藻醌;2-氨基-3-氯-1,4-萘醌(萘醌杀);2-氨基-3-氯-1,4-萘醌,灭藻醌;银杏内酯K;灭藻醌 标准品;甲醇中灭藻醌溶液,100ΜG/ML |
英文名称 | 2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE |
英文同义词 | 3-Chloro-2-aminonaphthalene-1,4-dione;O6K;2-Amino-3-chloro-1,4-naphthoquinone,95%;ASISCHEM T86788;06k;06k-50w;06K-Quinone;1,4-Naphthoquinone, 2-Amino-3-chloro- |
CAS号 | 2797-51-5 |
分子式 | C10H6ClNO2 |
分子量 | 207.61 |
EINECS号 | 220-529-2 |
植物来源 | 银杏 |
相关类别 | 试剂和补充物;卤代物;除草剂;药物杂质及中间体;有机化学 |
Mol文件 | 2797-51-5.mol |
结构式 |
2-氨基-3-氯-1,4-萘醌 性质
熔点 | 198-200 °C |
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沸点 | 310℃ |
密度 | 1.49 |
折射率 | 1.5790 (estimate) |
闪点 | 141℃ |
储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
水溶解性 | Insoluble in water |
溶解度 | 二甲基亚砜:250 mg/mL(1204.18 mM) |
形态 | 粉末 |
酸度系数(pKa) | 0.70±0.20(Predicted) |
颜色 | 橙色 |
LogP | 2.120 |
CAS 数据库 | 2797-51-5(CAS DataBase Reference) |
EPA化学物质信息 | 2-Amino-3-chloro-1,4-naphthoquinone (2797-51-5) |
NF-κB
Quinoclamine causes differentiation of U-937 cells into macrophage-like cells.
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC
50
of 1.7 μM.
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation.
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines.
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis.
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism.
Cell Viability Assay
Cell Line: | HepG2 cells |
Concentration: | 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM |
Incubation Time: | 24 hours |
Result: | Inhibited NF-κB activities in HepG2 cells. |
Western Blot Analysis
Cell Line: | HepG2 cells |
Concentration: | 0 μM, 1 μM, 2 μM, 4 μM |
Incubation Time: | 30 minutes |
Result: | Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells. |
安全信息
危险品标志 | T,N |
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危险类别码 | 36/37/38-23-22-50/53-36 |
安全说明 | 45-37/39-26-61-60 |
危险品运输编号 | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
WGK Germany | 3 |
RTECS号 | QL7350000 |
危险等级 | 6.1 |
海关编码 | 29223990 |
毒性 | LD50 oral in rat: 1360mg/kg |
提供商 | 语言 |
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英文
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