sodium 5-(sec-butyl)-5-ethylbarbiturate

sodium 5-(sec-butyl)-5-ethylbarbiturate Basic information

Product Name:	sodium 5-(sec-butyl)-5-ethylbarbiturate
Synonyms:	sodium 5-(sec-butyl)-5-ethylbarbiturate;Secbutobarbitone sodium;Sodium butabarbital;BUTABARBITAL SODIUM SALT;Asturidon;Bubarbital sodium;Bubartal;Prelital
CAS:	143-81-7
MF:	C10H14N2Na2O3
MW:	256.2093
EINECS:	205-611-8
Product Categories:	API's
Mol File:	143-81-7.mol

sodium 5-(sec-butyl)-5-ethylbarbiturate Chemical Properties

Melting point	The free acid mp 165-168°
EPA Substance Registry System	Butabarbital sodium (143-81-7)

Safety Information

MSDS Information

sodium 5-(sec-butyl)-5-ethylbarbiturate Usage And Synthesis

Originator	Butisol sodium,Wallace Labs,USA
Uses	Sedative-hypnotic.
Manufacturing Process	5-sec-Butyl-5-ethylbarbituric acid was prepared from diethyl ester of malonic acid in 3 steps. At the above malonic ester was reacted with C2H5Br and sodium ethylate producing the diethyl ester of ethylmalonic acid, which after a reaction with sodium ethylate and 2-butylbromide gave the ethyl-(2-butyl)- malonic acid diethyl ester. The last one produced the 5-sec-butyl-5-ethylbarbituric acid after a reaction with urea and sodium ethylate. 23 g sodium (1 mol) was dissolved in 300 ml alcohol. To this solution was added a solution of 5-sec-butyl-5-ethyl-barbituric acid (1 mol) in 800 ml alcohol. To a mixture was added 1000 ml benzene, which precipitated the sodium salt of the barbituric acid (butabarbital sodium). The product was filtered and dried.
Brand name	Butabarb (Alpharma); Butalan (Lannett); Buticaps (Medpointe); Butisol Sodium (Medpointe); Sarisol (Halsey).
Therapeutic Function	Hypnotic

sodium 5-(sec-butyl)-5-ethylbarbiturate Preparation Products And Raw materials

Raw materials

Tag:sodium 5-(sec-butyl)-5-ethylbarbiturate(143-81-7) Related Product Information

BUTABARBITAL sodium 5-(sec-butyl)-5-ethylbarbiturate

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