XENIN 25 ACETATE SALT
| 中文名称 | XENIN 25 ACETATE SALT |
|---|---|
| 中文同义词 | 爪蟾肽 25;XENIN 25醋酸盐 |
| 英文名称 | XENIN |
| 英文同义词 | H-Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-OH;XENIN 25 ACETATE SALT ≥95%;Human xenin;Human xenopsin;Xenopsin 25;L-Leucine,L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-a-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-;Xenin 25 acetate salt, ≥95% (HPLC);L-Leucine, L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl- |
| CAS号 | 144092-28-4 |
| 分子式 | C139H224N38O32S |
| 分子量 | 2971.57 |
| EINECS号 | |
| 相关类别 | 多肽;生化试剂;其他生化试剂;Xenin 25;Hormones;Obesity Research |
| Mol文件 | 144092-28-4.mol |
| 结构式 |  |
XENIN 25 ACETATE SALT 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Xenin is abundantly expressed in gastric, duodenal, and jejunal mucosa, and is found at lower levels in the pancreas. Xenin is released into the circulation postprandially and has been reported to stimulatepancreatic endocrine and exocrine secretion, inhibit gastrin secretion, and influence gastrointestinal motility. Xenin is highly homologous to neurotensin. Xenin and neurotensin are reported to have similar biological effects.
Both intracerebroventricular and intraperitoneal administration of xenin inhibit fasting-induced hyperphagia in wild-type mice in a dose-dependent manner. The intraperitoneal injection of xenin also reduces nocturnal intake in ad libitum–fed wild-type mice. The intraperitoneal injection of xenin increases Fos immunoreactivity in hypothalamic nuclei, including the paraventricular nucleus and the arcuate nucleus. Xenin reduces food intake in agouti and ob/ob mice. Gastric emptying rate is reduced by about 93% in xenin-treated mice compared to saline-treated control mice. The i.p. xenin injection significantly increases Fos-immunoreactive cells in the nucleus of the solitary tract of the brainstem, but not area postrema and dorsal motor nucleus of the vagus.
安全信息
| 安全说明 | 22-24/25 |
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