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| Product Name: | XENIN | | Synonyms: | H-Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-OH;XENIN 25 ACETATE SALT ≥95%;Human xenin;Human xenopsin;Xenopsin 25;L-Leucine,L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-a-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-;Xenin 25 acetate salt, ≥95% (HPLC);L-Leucine, L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl- | | CAS: | 144092-28-4 | | MF: | C139H224N38O32S | | MW: | 2971.57 | | EINECS: | | | Product Categories: | Xenin 25;Hormones;Obesity Research | | Mol File: | 144092-28-4.mol |  |
| | XENIN Chemical Properties |
| storage temp. | −20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white | | Sequence | Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu |
| | XENIN Usage And Synthesis |
| Uses | Peptide involved in the regulation of food intake that is released into the circulation from the gut mucosa after a meal. It may stimulate enzyme release from the exocrine pancreas | | Uses | Xenin 25 Acetate Salt can be used in biological study of hormonal responses to cholinergic input are different in humans with and without type 2 diabetes mellitus. | | in vivo | Both intracerebroventricular and intraperitoneal administration of xenin inhibit fasting-induced hyperphagia in wild-type mice in a dose-dependent manner. The intraperitoneal injection of xenin also reduces nocturnal intake in ad libitum–fed wild-type mice. The intraperitoneal injection of xenin increases Fos immunoreactivity in hypothalamic nuclei, including the paraventricular nucleus and the arcuate nucleus. Xenin reduces food intake in agouti and ob/ob mice[2]. Gastric emptying rate is reduced by about 93% in xenin-treated mice compared to saline-treated control mice. The i.p. xenin injection significantly increases Fos-immunoreactive cells in the nucleus of the solitary tract of the brainstem, but not area postrema and dorsal motor nucleus of the vagus[3]. |
| | XENIN Preparation Products And Raw materials |
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