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Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)

Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Suppliers list
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Tel: +8613336195806
Email: sales@capot.com
Products Intro: Product Name:5-Bromo-4-methylpyrimidine
CAS:1439-09-4
Purity:98%(Min.HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
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Products Intro: CAS:1439-09-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Accela ChemBio Inc.
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Products Intro: Product Name:5-Bromo-4-methylpyrimidine
CAS:1439-09-4
Purity:>=98% Package:0.25g;1g;5g;10g;25g
Company Name: Alchem Pharmtech,Inc.
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Products Intro: Product Name:5-Bromo-4-methylpyrimidine
CAS:1439-09-4
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-01973
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Email: coupling278191416@hotmail.com
Products Intro: Product Name:Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)
CAS:1439-09-4
Purity:99% HPLC Package:5KG;1KG

Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) manufacturers

Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Basic information
Product Name:Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)
Synonyms:Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI);5-bromo-4-methylpyrimidine;Pyrimidine, 5-bromo-4-methyl-;Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) ISO 9001:2015 REACH;5-Bromo-4-methylpyrimidine 98%
CAS:1439-09-4
MF:C5H5BrN2
MW:173.01
EINECS:
Product Categories:Heterocycle-Pyrimidine series;PYRIMIDINE
Mol File:1439-09-4.mol
Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Structure
Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Chemical Properties
Melting point 215℃
Boiling point 221.3±20.0℃ (760 Torr)
density 1.596±0.06 g/cm3 (20 ºC 760 Torr)
Fp 87.7±21.8℃
storage temp. 2-8°C
pka0.50±0.16(Predicted)
AppearanceColorless to light yellow Liquid
InChIInChI=1S/C5H5BrN2/c1-4-5(6)2-7-3-8-4/h2-3H,1H3
InChIKeyALRPHTZYJPXPGN-UHFFFAOYSA-N
SMILESC1=NC=C(Br)C(C)=N1
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 26-39
HazardClass IRRITANT
HS Code 2933599590
MSDS Information
Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Usage And Synthesis
Synthesis
5-Bromopyrimidine

4595-59-9

Methyllithium

917-54-4

Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)

1439-09-4

An ether solution of methyl lithium (109 mmol, 1.09 M, 100 mL) was added dropwise to an ether (100 mL) solution of 5-bromopyrimidine (17.3 g, 109 mmol) at room temperature. The resulting reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, water (1.96 mL, 109 mmol) and a solution of tetrahydrofuran (150 mL) of 2,3-dichloro-5,6-dicyano-p-benzoquinone (24.7 g, 109 mmol) were added to the reaction mixture, and stirring was continued for 16 hours at room temperature. Upon completion of the reaction, water and ethyl acetate were added for extraction and the organic layer was separated. The organic layer was washed with 1 M aqueous sodium hydroxide, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=1/1) to afford the target product 5-bromo-4-methylpyrimidine (2.9 g, 15% yield). Product properties: yellow oil. 1H-NMR (CDCl3) δ: 2.65 (s, 3H), 8.72 (s, 1H), 8.98 (s, 1H).

References[1] Patent: WO2009/57827, 2009, A1. Location in patent: Page/Page column 167
Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) Preparation Products And Raw materials
Raw materials5-BROMO-4-CHLORO-6-METHYLPYRIMIDINE-->Methyllithium-->5-Bromopyrimidine-->Water-->Diethyl ether-->2,3-Dichloro-5,6-dicyano-1,4-benzoquinone-->Tetrahydrofuran
Preparation ProductsPyrimidine, 5-methoxy-4-methyl- (8CI,9CI)
Tag:Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)(1439-09-4) Related Product Information
5-Bromo-2,4-dichloro-6-methylpyrimidine 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 4-AMINO-5-BROMO-6-METHYLPYRIMIDINE 2-Amino-5-bromo-4,6-dimethylpyrimidine 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2-Amino-4-methyl-5-bromopyrimidine 5-Bromo-4-phenylpyrimidine 5-BROMO-4-HYDRAZINO-6-METHYLPYRIMIDINE 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- 2-(5-BROMO-2-CHLOROPYRIMIDIN-4-YL)-2-(1-METHYL-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-2-YLIDEN)ACETONITRILE 2-(1H-BENZO[D]IMIDAZOL-2-YL)-2-(5-BROMO-2-CHLORO-6-METHYLPYRIMIDIN-4-YL)ACETONITRILE 5-BROMO-4-HYDRAZINO-2,6-DIPHENYLPYRIMIDINE 2-AMINO-4-METHYL-5-BROMO-6-TRIFLUOROPYRIMIDINE 4,5-DIBROMO-2,6-DIPHENYLPYRIMIDINE SULFABROMOMETHAZINE (PHENYL-13C6) 2-(5-BROMO-2-CHLORO-6-METHYLPYRIMIDIN-4-YL)-2-(1-METHYL-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-2-YLIDEN)ACETONITRILE

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