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Finetech Industry Limited |
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| Products Intro: |
Product Name:1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]-imidazole-2,5(1H,3H)-dione
CAS:10095-06-4
Purity:98% Package:1g,10g,25g,100g,500g,1kg
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- Temgicoluril
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- $29.00 / 25mg
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2025-12-05
- CAS:10095-06-4
- Min. Order:
- Purity: 99.80%
- Supply Ability: 10g
- mebikar
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- $0.00 / 25KG
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2025-12-01
- CAS:10095-06-4
- Min. Order: 1KG
- Purity: 95.0%
- Supply Ability: 10000KGS
- mebikar
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- $72.00 / 10Grams
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2025-09-26
- CAS:10095-06-4
- Min. Order: 10Grams
- Purity: 99.99%
- Supply Ability: 100Tons
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| | mebikar Basic information |
| Product Name: | mebikar | | Synonyms: | mebikar;2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione;3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione;4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one;Mebicar;1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione;1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone;1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione | | CAS: | 10095-06-4 | | MF: | C8H14N4O2 | | MW: | 198.22 | | EINECS: | | | Product Categories: | | | Mol File: | 10095-06-4.mol |  |
| | mebikar Chemical Properties |
| Melting point | 226 - 229?C | | Boiling point | 362.2±42.0 °C(Predicted) | | density | 1.237±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | -0.49±0.20(Predicted) | | color | White to Off-White | | InChI | InChI=1S/C8H14N4O2/c1-9-5-6(11(3)7(9)13)12(4)8(14)10(5)2/h5-6H,1-4H3 | | InChIKey | XIUUSFJTJXFNGH-UHFFFAOYSA-N | | SMILES | CN1C(N(C2N(C(N(C21)C)=O)C)C)=O |
| | mebikar Usage And Synthesis |
| Uses | Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2]. | | Definition | ChEBI: Mebicar is an imidazolidinone. | | in vivo | Temgicoluril (10 mg/kg; Oral gavage; 3 weeks) has a preventive effect on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice[2]. | Animal Model: | Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice[2] | | Dosage: | 10 mg/kg | | Administration: | Oral gavage (i.g.); 3 weeks | | Result: | Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice.
Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure.
Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.
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| | References | [1] Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennoste? spektra psikhotropnogo de?stviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian. PMID:6104993
[2] Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25(1):49-58. DOI:10.1159/000489634 |
| | mebikar Preparation Products And Raw materials |
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