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ChemicalBook Optimization Suppliers |
| 名前: |
Alfa Aesar |
| 電話番号: |
400-6106006 |
| 電子メール: |
saleschina@alfa-asia.com |
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| 融点 | 182-183 °C (dec.)(lit.) | | 沸点 | 524.7±50.0 °C(Predicted) | | 比重(密度) | 1.1342 (rough estimate) | | 屈折率 | 111 ° (C=0.8, 0.04mol Ethanolic HCl) | | 貯蔵温度 | Sealed in dry,Room Temperature | | 溶解性 | Soluble in DMSO (up to 20 mg/ml). | | 外見 | White to off-white solid. | | 酸解離定数(Pka) | 2.22±0.10(Predicted) | | 色 | White or off-white | | 光学活性 (optical activity) | [α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl | | BRN | 2339626 | | 安定性： | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. | | CAS データベース | 2799-07-7(CAS DataBase Reference) |
| 主な危険性 | Xn | | Rフレーズ | 22 | | Sフレーズ | 22-24/25 | | WGK Germany | 3 | | RTECS 番号 | AY7710000 | | HSコード | 29309090 | | 毒性 | dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993, |
| | S-トリチル-L-システイン Usage And Synthesis |
| 外観 | 白色～ほとんど白色粉末～結晶 | | 説明 | S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines. | | 化学的特性 | almost white to light yellow granular powder | | 使用 | (+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions. | | 使用 | A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen. | | 定義 | ChEBI: (2R)-2-amino-3-[(triphenylmethyl)thio]propanoic acid is a benzenoid aromatic compound. | | 生物活性 | Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity. | | 貯蔵 | Store at +4°C | | 参考文献 | 1) DeBonis et al. (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities; Mol. Cancer Ther. 3 1079
2) Brier et al. (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5; Biochemistry 43 13072
3) Skoufias et al. (2006) S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression; J. Biol. Chem., 281 17559 |
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