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| 化学名: | チロシジン | | 英語化学名: | TYROTHRICIN | | 别名: | bactratycin;coltirot;duboscrudecrystals;hydrotricine;3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-3,22,25-tris(phenylmethyl)-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid;3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-azanyl-2-oxo-ethyl)-9-(3-azanylpropyl)-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-3,22,25-tris(phenylmethyl)-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid;intradermtyrothricin;martricin | | CAS番号: | 1404-88-2 | | 分子式: | C6H13NO5 | | 分子量: | 179.17112 | | EINECS: | 215-771-0 | | カテゴリ情報: | | | Mol File: | 1404-88-2.mol |  |
| 貯蔵温度 | Store at -20°C | | 溶解性 | Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol. | | EPAの化学物質情報 | Tyrothricin (1404-88-2) |
| Sフレーズ | 22-24/25 | | WGK Germany | 2 | | RTECS 番号 | YP2975000 | | 毒性 | LD50 in mice (mg/kg): >1500 s.c.; 100 i.p.; >3000 orally (Sous) |
| | チロシジン Usage And Synthesis |
| 解説 | チロシジン,Aの塩酸塩は融点204～242 ℃．[α]D－111°(50％ エタノール)．水に易溶，メタノールに微溶．いずれもグラム陽性菌および陰性菌に有効で，細胞質膜に作用して透過性を乱す．毒性はマウス最小致死量5 mg/kg(静脈)． | | 製造 | グラミシジンとともに，枯草菌Bacillus brevisの培養液から得られる環状ペプチド抗菌性物質の混合物．A，B，Cの3種類が知られている． | | 化学的特性 | White or almost white powder. | | 使用 | Tyrothricin is a complex of two unrelated peptide families, gramicidin complex and tyrocidines complex, produced by Bacillus brevis and discovered by Dubos in 1939. Typically, tyrothricin is composed of 20% of the linear pentadecylpeptide gramicidins and 80% of cyclic decapeptide tyrocidines. Both the gramicidins and tyrocidines act by disrupting bacterial cell wall integrity, but by differing mechanisms. Tyrothricin is used clinically for bacterial skin infections in some countries. | | 定義 | An antibiotic produced by growth of Bacillus brevis. It consists of a mixture of antibiotics, principally gramicidin and tyrocidine. Gramicidin is the more active component. Use is generally limited to local external applications. It is active against some Gram-positive bacteria, including species of pneumococci, streptococci, and staphylococci. | | brand name | Bactratycin (Wallace). |
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