2-(4-羟基苯基)苯并[B]噻吩-6-醇
| 中文名称 | 2-(4-羟基苯基)苯并[B]噻吩-6-醇 |
|---|---|
| 中文同义词 | 2-(4-羟苯基)-苯并[B]噻吩-6-醇;2-(4-羟基苯基)苯并[B]噻吩-6-醇;雷洛昔芬杂质4;雷洛昔芬杂质8;2-(4-羟苯基)苯并[B]噻吩-6-醇;2-(4-羟基苯基)-1-苯并噻吩-6-醇 |
| 英文名称 | 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol |
| 英文同义词 | 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol;2-(4-hydroxyphenyl)-1-benzothiophene-6-ol;Raloxifene InterMediate;2-(4-Hydroxyphenyl)benzo[b]thiophen-6-ol;6-Hydroxy-2-(4-Hydroxyphenyl)Benzo[B]Thiophene;2-(4-hydroxyphenyl)-1-benzothiophen-6-ol;Raloxifene Impurity 4;2-(4-Hydroxyphenyl)benzothiophene-6-ol |
| CAS号 | 63676-22-2 |
| 分子式 | C14H10O2S |
| 分子量 | 242.29 |
| EINECS号 | |
| 相关类别 | 医药中间体 |
| Mol文件 | 63676-22-2.mol |
| 结构式 | ![2-(4-羟基苯基)苯并[B]噻吩-6-醇 结构式](CAS2/GIF/63676-22-2.gif) |
2-(4-羟基苯基)苯并[B]噻吩-6-醇 性质
| 熔点 | 295 °C(dec.) |
|---|---|
| 沸点 | 477.0±30.0 °C(Predicted) |
| 密度 | 1.383 |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.32±0.15(Predicted) |
| 颜色 | 浅灰色 |
Estrogen receptor modulator 1 (compound 18) 是一种口服活性的选择性 estrogen receptor 调节剂(SERM)，pIC50值为0.46。Estrogen receptor modulator 1具有潜在的抗肿瘤活性。
| Target | Value |
|
ER
(Cell-free assay) | 0.46(pIC50) |
Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation.
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days.
Cell Proliferation Assay
| Cell Line: | T47D:A18/PKCα and T47D:A18-TAM1 cells |
| Concentration: | 100 nM |
| Incubation Time: | 10 days |
| Result: | Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation. |
Cell Viability Assay
| Cell Line: | MCF-7:5C cells |
| Concentration: | 100 nM |
| Incubation Time: | 9 days |
| Result: | Significantly inhibited the growth of MCF-7:5C cells. |
Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors.
| Animal Model: | 4-6 week old athymic mice (Harlan-Sprague-Dawley) |
| Dosage: | 1.5 mg/animal |
| Administration: | p.o. ; daily for 2 weeks |
| Result: | Significantly reduced tumor volume. |
安全信息
| 海关编码 | 2934.99.4400 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | H1628 | 2-(4-羟苯基)苯并[b]噻吩-6-醇 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol | 63676-22-2 | 50mg | 265元 |
| 2024/04/30 | HY-110201 | Estrogen receptor modulator 1 | 1 mg | 348元 |