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Product Name:N-acetyl-2-carboxy Benzenesulfonamide Exclusive
CAS:849067-18-1
Purity:98% Package:1mg;5mg;10mg
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Product Name:N-acetyl-2-carboxy Benzenesulfonamide
CAS:849067-18-1
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Product Name:N-acetyl-2-carboxy Benzenesulfonamide
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Product Name:N-Acetyl-2-carboxybenzenesulfonamide
CAS:849067-18-1
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Product Name:N-acetyl-2-carboxy Benzenesulfonamide
CAS:849067-18-1
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| | N-acetyl-2-carboxy Benzenesulfonamide Basic information |
| Product Name: | N-acetyl-2-carboxy Benzenesulfonamide | | Synonyms: | N-acetyl-2-carboxy Benzenesulfonamide;N-acetyl-2-carboxy Benzenesulfonamide Exclusive;ADVANFQVCYCSNR-UHFFFAOYSA-N;Benzoic acid, 2-[(acetylamino)sulfonyl]-;2-(N-Acetylsulfamoyl)benzoic acid | | CAS: | 849067-18-1 | | MF: | C9H9NO5S | | MW: | 243.24 | | EINECS: | | | Product Categories: | | | Mol File: | 849067-18-1.mol |  |
| | N-acetyl-2-carboxy Benzenesulfonamide Chemical Properties |
| Melting point | 178-180 °C | | density | 1.463±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 2.79±0.36(Predicted) |
| | N-acetyl-2-carboxy Benzenesulfonamide Usage And Synthesis |
| Description | N-acetyl-2-carboxy Benzenesulfonamide is a structural analog of aspirin that acts as a non-selective inhibitor of cyclooxygenase (COX) with a COX-2 selectivity index of 0.23. In vitro studies showed that N-acetyl-2-carboxy Benzenesulfonamide is a more potent inhibitor of COX-1/COX-2 with IC50 values of 0.06 μM and 0.25 μM, respectively, than aspirin with IC50 values of 0.35 μM and 2.4 μM, respectively. | | in vitro | previous in-vitro cox-1/cox-2 inhibition studies showed that n-acetyl-2-carboxy benzenesulfonamide was a more potent inhibitor than aspirin, and like aspirin. moreover, n-acetyl-2-carboxy benzenesulfonamide was found to be a nonselective cox-2 inhibitor. in addition, the molecular modeling (docking) study demonstrated that the so2nhcoch3 substituent present in n-acetyl-2-carboxy benzenesulfonamide, like the acetoxy substituent in aspirin, was suitably positioned to acetylate the ser530 hydroxyl group in the cox-2 primary binding site [1]. | | in vivo | animal study showed that n-acetyl-2-carboxy benzenesulfonamide and its c-4 2,4-difluorophenyl derivative had superior antiinflammatory activity (oral dosing) in a carrageenan-induced rat paw edema assay compared to aspirin. in addition, n-acetyl-2-carboxy benzenesulfonamide and its c-4 2,4-difluorophenyl derivative exhibited comparable analgesic activity to iflunisal, and superior analgesic activity compared to aspirin [1]. | | IC 50 | 0.06 and 0.25 μm for cox-1 and cox-2, respectively | | references | [1] chen, q. h.,rao, p.n.p., and knaus, e.e. design, synthesis, and biological evaluation of n-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (cox-2) inhibitors. bioorganic & medicinal chemistry 13, 2459-2468 (2005). |
| | N-acetyl-2-carboxy Benzenesulfonamide Preparation Products And Raw materials |
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