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| | RbBP5 (human recombinant) Basic information |
| | RbBP5 (human recombinant) Chemical Properties |
| | RbBP5 (human recombinant) Usage And Synthesis |
| Description | Retinoblastoma-binding protein 5 (RbBP5) is a ubiquitously expressed nuclear protein that contains WD40 repeat-like domains. RbBP5 binds directly to tumor suppressor retinoblastoma protein (RB) and regulates cell proliferation. Interaction of RbBP5 occurs preferentially with underphosphorylated RB through the E1A-binding pocket B. RbBP5 is also an important component of the multi-subunit SET1 lysine methyltransferase protein complex, which includes MLL1. RbBP5 interacts directly with WDR5 contributing to the activation of the MLL1 core protein complex. MLL1-4 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation. | | References | [1] M. SUGANO N M K Tsuchida. Nifedipine Prevents Apoptosis of Endothelial Cells Induced By Oxidized Low-density Lipoproteins[J]. Journal of Cardiovascular Pharmacology, 2002, 40 1: 146-152. DOI: 10.1097/00005344-200207000-00018
[2] VANJA AVDIC. Structural and biochemical insights into MLL1 core complex assembly.[J]. Structure, 2011, 19 1: 101-108. DOI: 10.1016/j.str.2010.09.022
[3] ZAIN ODHO Jon R W Stacey M Southall. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.[J]. The Journal of Biological Chemistry, 2010, 285 43: 32967-32976. DOI: 10.1074/jbc.m110.159921
[4] YALI DOU. Regulation of MLL1 H3K4 methyltransferase activity by its core components[J]. Nature Structural & Molecular Biology, 2006, 13 8: 713-719. DOI: 10.1038/nsmb1128
[5] PENGFEI WANG. Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.[J]. Molecular and Cellular Biology, 2009, 29 22: 6074-6085. DOI: 10.1128/mcb.00924-09 |
| | RbBP5 (human recombinant) Preparation Products And Raw materials |
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