| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Email: |
|
| Products Intro: |
Product Name:LY2140023 hydrochloride
CAS:635318-26-2
Purity:99% HPLC Package:50Mg,100Mg,500Mg,1g,5g,10g,50g,100g,500g,1kg Remarks:XYA0455
|
| Company Name: |
LETOPHARM LIMITED
|
| Tel: |
+86-21-5821 5861 |
| Email: |
sales@letopharm.com |
| Products Intro: |
Product Name:LY2140023 hydrochloride
CAS:635318-26-2
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:LY2140023 hydrochloride
CAS:635318-26-2
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
|
| Company Name: |
ShangHai ChuanQian Chemcial Technique Centre
|
| Tel: |
15869524721 |
| Email: |
3525679403@qq.com |
| Products Intro: |
Product Name:LY2140023 Hydrochloride
CAS:635318-26-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,10G
|
|
| | LY2140023 hydrochloride Basic information |
| | LY2140023 hydrochloride Chemical Properties |
| storage temp. | 4°C, stored under nitrogen |
| | LY2140023 hydrochloride Usage And Synthesis |
| Biological Activity | Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research[1][2].
Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM[2].LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].
Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1]. | | References | [1]. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70. [2]. Y Anne Pak, et al. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug Metab Dispos. 2017 Feb;45(2):137-144. |
| | LY2140023 hydrochloride Preparation Products And Raw materials |
|