24-HYDROXYCHOLESTEROL
| 中文名称 | 24-HYDROXYCHOLESTEROL |
|---|---|
| 中文同义词 | |
| 英文名称 | 24-Hydroxycholesterol |
| 英文同义词 | Cholest-5-ene-3,24-diol, (3β)- |
| CAS号 | 30271-38-6 |
| 分子式 | C27H46O2 |
| 分子量 | 402.65 |
| EINECS号 | |
| 相关类别 | Pharmaceuticals, Intermediates & Fine Chemicals, Steroids |
| Mol文件 | 30271-38-6.mol |
| 结构式 |  |
24-HYDROXYCHOLESTEROL 性质
| 沸点 | 513.1±23.0 °C(Predicted) |
|---|---|
| 密度 | 1.03±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 15.03±0.70(Predicted) |
| 颜色 | 白色至类白色 |
24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation.
Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1 + islets. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain.