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| 化学名: | グラチラマー酢酸塩 | | 英語化学名: | Glatiramer acetate | | 别名: | ProtiraMer;GaltiraMer acetate;GlatiraMer-d7;Glatiramer acetate [USAN:BAN];GLATIRAMER ACETATE;l-glutamic acid polymer with l-alanine, l-lysine and l-tyrosine, acetate (salt);511: PN: WO2010103292 PAGE: 64 claiMed sequence;L-Alanine polyMer with L-GlutaMic Acid L-Lysine L-Tyrosine Acetate | | CAS番号: | 147245-92-9 | | 分子式: | C25H45N5O13 | | 分子量: | 623.66 | | EINECS: | 814-981-5 | | カテゴリ情報: | Amino Acids & Derivatives;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;API | | Mol File: | 147245-92-9.mol |  |
| | グラチラマー酢酸塩 Usage And Synthesis |
| Originator | Copaxone,Teva Pharmaceuticals,Israel | | 使用 | Glatiramer Acetate-Dx is labelled Glatiramer Acetate (G406800) which is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis. | | 使用 | Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis. | | Manufacturing Process | Glatiramer Acetate is water soluble copolypeptide with molecular weight
15,000-25,000.
Copolymer is prepared by copolymerization of the N-carboxyanhydrides of
tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried
out at ambient temperature in anhydrous dioxane with diethylamine as
initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine
= 1:6:4.54:2. | | brand name | Copaxone (Teva). | | Therapeutic Function | Immunomodulator | | 臨床応用 | Immunomodulating drug:
Treatment for patients at a high risk of developing
multiple sclerosis and for reduction in relapses in
ambulatory patients | | 代謝 | A substantial fraction of a subcutaneous dose of
glatiramer is believed to be hydrolysed locally. Some of
the injected dose is also presumed to enter the lymphatic
system, either intact or partially hydrolysed. |
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