无中文名称
| 中文名称 | 无中文名称 |
|---|---|
| 中文同义词 | 7-[5-[[4-[4-[(二甲基氨基)磺酰基]-1-哌嗪基]苯氧基]甲基]-1,3-二甲基-1H-吡唑-4-基]-1-[2-(4-吗啉基)乙基]-3-[3-(1-萘基氧基)丙基]-1H-吲哚-2-羧酸;MCL-1抑制剂(A-1210477);BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101;7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-吗啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸;化合物A-1210477;A-1210477,MCL-1抑制剂 |
| 英文名称 | A-1210477 |
| 英文同义词 | A-1210477;Abbvie Mcl-1 Inhibitor;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid;7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;CS-2202;CS-2151;A-1210477;A 1210477;A1210477;1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]- |
| CAS号 | 1668553-26-1 |
| 分子式 | C46H55N7O7S |
| 分子量 | 850.04 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;抑制剂;细胞生物学试剂;Inhibitors |
| Mol文件 | 1668553-26-1.mol |
| 结构式 |  |
无中文名称 性质
| 沸点 | 1027.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 不溶于DMSO；不溶于水；不溶于乙醇 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.43±0.30(Predicted) |
|
Mcl-1 0.45 nM (Ki) |
Bcl-2 132 nM (Ki) |
Bfl-1 660 nM (Ki) |
Bcl-W 2280 nM (Ki) |
Apoptosis
|
A-1210477 (10 μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC 50 of approximately 1 μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC 50 <10 μM, confirming that A-1210477 can kill MCL-1-dependent cell lines.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12468 | A-1210477 | 1 mg | 266元 | |
| 2024/01/25 | HY-12468 | 7-(5-((4-(4-(N,N-二甲基氨基磺酰)哌嗪-1-基)苯氧基)甲基)-1,3-二甲基-1H-吡唑-4-基)-1-(2-吗啉乙基)-3-(3-(萘-1-基氧基)丙基)-1H-吲哚-2-甲酸 A-1210477 | 1668553-26-1 | 5mg | 700元 |