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ChemicalBook Optimization Suppliers |
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| 化学名: | αテトラロン | | 英語化学名: | 1-Tetralone | | 别名: | KETOTETRAHYDRONAPHTHALENE;1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE;1-TETRALONE;3,4-DIHYDRO-1-(2H)NAPHTHALENEONE;1,2,3,4-Tetrahydro-1-oxonaphthalene;1-Tetralone,97%;1(2H)-Naphthalenone, 3,4-dihydro-;à-Tetralone | | CAS番号: | 529-34-0 | | 分子式: | C10H10O | | 分子量: | 146.19 | | EINECS: | 208-460-6 | | カテゴリ情報: | Bioactive Small Molecules;Building Blocks;C10;Carbonyl Compounds;Cell Biology;Chemical Synthesis;Ketones;Organic Building Blocks;T;PHARMACEUTICAL INTERMEDIATES;Cardiovascular & Blood System Agents;pharmaceutical;bc0001;529-34-0 | | Mol File: | 529-34-0.mol |  |
| | αテトラロン Usage And Synthesis |
| 外観 | 赤黄色～赤褐色, 澄明の液体 | | 溶解性 | エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。 | | 化学的特性 | Clear amber to brown oily liquid | | 使用 | 1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential. | | Synthesis Reference(s) | Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8 | | 純化方法 | Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.] |
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