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BOC Sciences
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Product Name:Formycin A
CAS:6742-12-7
Purity:97%
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| | 7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Basic information |
| Product Name: | 7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE | | Synonyms: | 3-d)pyrimidin-3-yl)-1,4-anhydro-1-c-(7-amino-1h-pyrazolo((s)-d-ribito;3-d)pyrimidine,7-amino-3-beta-d-ribofuranosyl-1h-pyrazolo(;7-amino-3-beta-d-ribofuranosyl-1h-pyrazolo(4,3-d)pyrimidine;formycin;8-AZA-9-DEAZAADENOSINE MONOHYDRATE;7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE;FORMYCIN MONOHYDRATE;FORMYCIN A MONOHYDRATE | | CAS: | 6742-12-7 | | MF: | C10H13N5O4 | | MW: | 267.25 | | EINECS: | | | Product Categories: | | | Mol File: | 6742-12-7.mol | ![7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Structure](CAS/GIF/6742-12-7.gif) |
| | 7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Chemical Properties |
| Melting point | 141-144 °C (decomp) | | Boiling point | 709.5±60.0 °C(Predicted) | | density | 1.771±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: soluble1mg/mL | | form | powder | | pka | 8.37±0.50(Predicted) | | color | white to off-white | | BRN | 624229 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | UR0719000 |
| | 7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Usage And Synthesis |
| Description | Formycin (Formycin A) is isolated
from Nocardia interforma and from Streptomyces
lavendulae , . The antibiotic
is effective against Xanthomonas oryzae
and Pellicularia filamentosa. Its activity against
Yoshida rat sarcoma cell is enhanced by coformycin.
Formycin B inhibits Xanthomonas
oryzae and interferes with multiplication of influenza A virus in the cells of chick
chorioallantoic membrane . Oxoformycin
B shows no activity against Xanthomonas
oryzae . | | Uses | Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities[1][2]. | | Definition | ChEBI: Formycin A is a formycin. It has a role as an antineoplastic agent. | | IC 50 | HIV-1: 10 μM (EC50) | | References | [1] Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88(1):354-63. DOI:10.1128/JVI.02444-13
[2] Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86(2). DOI:10.1128/AEM.01971-19 |
| | 7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Preparation Products And Raw materials |
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