CLOZAPINE-D3 manufacturers
- Clozapine-D3
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2026-05-11
- CAS:1215691-72-7
- Purity:
- Supply Ability: 10g
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| | CLOZAPINE-D3 Basic information |
| Product Name: | CLOZAPINE-D3 | | Synonyms: | CLOZAPINE-D3;QZUDBNBUXVUHMW-FIBGUPNXSA-N;[2H3]-Clozapine;Clozapine-d3
Discontined. Please see C587502 | | CAS: | 1215691-72-7 | | MF: | C18H19ClN4 | | MW: | 326.83 | | EINECS: | | | Product Categories: | | | Mol File: | 1215691-72-7.mol |  |
| | CLOZAPINE-D3 Chemical Properties |
| | CLOZAPINE-D3 Usage And Synthesis |
| Uses | Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4][5]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. DOI:10.1021/cn400189s
[3] Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2. DOI:10.1016/0922-4106(94)90047-7
[4] Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40. DOI:10.1016/s0304-3940(00)01225-8
[5] Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. DOI:10.1007/s00213-012-2809-7 |
| | CLOZAPINE-D3 Preparation Products And Raw materials |
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