KLH45
中文名称 | KLH45 |
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中文同义词 | 化合物 T24263;化合物KLH45 |
英文名称 | KLH45 |
英文同义词 | KLH45;N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide;KLH45 >=98% (HPLC);2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]- |
CAS号 | 1632236-44-2 |
分子式 | C24H25F3N4O2 |
分子量 | 458.48 |
EINECS号 | |
相关类别 | |
Mol文件 | 1632236-44-2.mol |
结构式 |
KLH45 性质
沸点 | 561.0±60.0 °C(Predicted) |
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密度 | 1.29±0.1 g/cm3(Predicted) |
溶解度 | DMSO:30.0(最大浓度 mg/mL);65.43(最大浓度 mM) 乙醇:30.0(最大浓度 mg/mL);65.43(最大浓度 mM) |
酸度系数(pKa) | -1.76±0.20(Predicted) |
KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.
KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.
Cell Viability Assay
Cell Line: | COS-7 cells. |
Concentration: | 2 μM. |
Incubation Time: | 16 h. |
Result: | Selectively blocked DDHD2 activity. |
KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2
−/−
mice.
Animal Model: |
Mice.
|
Dosage: | 5-40 mg/kg. |
Administration: | IP, once. |
Result: |
Did not show altered brain TAGs.
|
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-103060 | KLH45 | 1 mg | 545元 | |
2024/01/25 | HY-103060 | KLH45 KLH45 | 1632236-44-2 | 5mg | 1200元 |