| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:KLH 45
CAS:1632236-44-2
Purity:98% by HPLC Remarks:KLH 45 is a selective, potent and irreversible inhibitor of DDHD domain containing 2 (DDHD2) with IC50 value of 1.3 nM. It is selective for DDHD2 over 40 other serine hydrolases. It shows cross-reacti
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| Product Name: | KLH45 | | Synonyms: | KLH45;N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide;KLH45 >=98% (HPLC);2H-1,2,3-Triazole-2-carboxamide, N-cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]- | | CAS: | 1632236-44-2 | | MF: | C24H25F3N4O2 | | MW: | 458.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1632236-44-2.mol |  |
| | KLH45 Chemical Properties |
| Boiling point | 561.0±60.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | solubility | DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM) | | pka | -1.76±0.20(Predicted) |
| | KLH45 Usage And Synthesis |
| Description | KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC50 = 1.3 nM). It is selective for DDHD2 over greater than 50 serine hydrolases, including DDHD1 and Sec23ip, but does inhibit α/β-hydrolase domain-containing protein 6 (ABHD6). It inhibits DDHD2 and ABHD6 in Neuro2A cells when used at a concentration of less than 10 nM and inhibits DDHD2 by greater than 95% at a concentration of 25 nM. KLH45 (2 μM) prevents increases in triacylglycerol (TAG) hydrolase activity in HEK293T cell lysates expressing recombinant DDHD2 and incubated with a radiolabeled TAG substrate. It decreases TAG levels in the CNS of mice when administered at a dose of 20 mg/kg twice per day for four days. KLH45 (2 μM) also reverses DDHD2-induced lipid droplet reduction in COS-7 cells expressing recombinant DDHD2 and loaded with oleic acid. | | Uses | KLH45 is a novel selective inhibitor of DDHD2. |
| | KLH45 Preparation Products And Raw materials |
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