BMS-8

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BMS-8 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:BMS-8
CAS:1675201-90-7
Purity:99.06% Package:1mg;33USD|5mg;76USD|10mg;133USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:BMS-8
CAS:1675201-90-7
Purity:98% Package:1mg Remarks:V3256
Company Name: Aladdin Scientific
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Products Intro: Product Name:BMS-8
CAS:1675201-90-7
Purity:>=98.0% Package:$95.9/5mg;$165.9/10mg;$345.9/25mg;$550.9/50mg;$950.9/100mg;Bulk package Remarks:98.0%
Company Name: InvivoChem  Gold
Tel: 13549236410
Email: sales@invivochem.cn
Products Intro: Product Name:BMS-8
CAS:1675201-90-7
Purity:98% HPLC Package:1mg Remarks:V3256
Company Name: Suzhou Zhixin Biotechnology Co., Ltd.  Gold
Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Products Intro: Product Name:BMS-8
CAS:1675201-90-7
Purity:99.18% Package:1g;10g;100g

BMS-8 manufacturers

  • BMS-8
  • BMS-8 pictures
  • $33.00 / 1mg
  • 2026-04-13
  • CAS:1675201-90-7
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  • Purity: 99.06%
  • Supply Ability: 10g
BMS-8 Basic information
Product Name:BMS-8
Synonyms:BMS-8;2-Piperidinecarboxylic acid, 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-;1-(3-bromo-4-((2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;PPI,BMS 8,BMS8,inhibit,BMS-8,Inhibitor,PD-L1,PD-1;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;BMS-8, 10 mM in DMSO;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid , BMS-8
CAS:1675201-90-7
MF:C27H28BrNO3
MW:494.42
EINECS:
Product Categories:
Mol File:1675201-90-7.mol
BMS-8 Structure
BMS-8 Chemical Properties
Boiling point 616.9±55.0 °C(Predicted)
density 1.334±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Methanol: slightly soluble
form A crystalline solid
pka2.35±0.20(Predicted)
color White to off-white
InChIKeyQRXBPPWUGITQLE-UHFFFAOYSA-N
SMILESN1(CC2=CC=C(OCC3C=CC=C(C4=CC=CC=C4)C=3C)C(Br)=C2)CCCCC1C(O)=O
Safety Information
MSDS Information
BMS-8 Usage And Synthesis
DescriptionBMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.
UsesBMS-8 is inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.
References[1] KATARZYNA GUZIK. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1[J]. Journal of Medicinal Chemistry, 2017, 60 13: 5857-5867. DOI: 10.1021/acs.jmedchem.7b00293
BMS-8 Preparation Products And Raw materials
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